10-methyl-5,10-dideazaminopterin diethyl ester

Base Information

Chemical Name:10-methyl-5,10-dideazaminopterin diethyl ester
CAS No.:123751-78-0
Molecular Formula:C₂₆H₃₂N₆O₅
Molecular Weight:508.577
Hs Code.:

Synonyms:

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Chemical Property of 10-methyl-5,10-dideazaminopterin diethyl ester

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Technology Process of 10-methyl-5,10-dideazaminopterin diethyl ester

There total 8 articles about 10-methyl-5,10-dideazaminopterin diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 123751-72-4
4-amino-4-deoxy-10-methyl-5,10-dideazapteroic acid

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 123751-78-0
10-methyl-5,10-dideazaminopterin diethyl ester

Guidance literature:: With triethylamine; isobutyl chloroformate; In dimethyl sulfoxide; for 19.5h; Ambient temperature;
DOI:10.1021/jm00164a033

Reference yield:

: 619-64-7
p-ethylbenzoic acid

: 123751-78-0
10-methyl-5,10-dideazaminopterin diethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) LDA, HMPA / 1.) THF, hexane, a) 0-5 deg C, 6 h, b) RT temp., 22 h, 2.) 0-5 deg C

2: 27 percent / NaHCO₃ / dimethylformamide / 72 h / Ambient temperature

3: 95 percent / 1N HCl / acetic acid / 18 h / Ambient temperature

4: 94 percent / K₂CO₃ / 0.67 h / 60 °C

5: Et₃N / tetrahydrofuran / 1.) -20 deg C, 2.) RT, 15 h

6: 91 percent / conc. NH₄OH / methanol / 72 h / Ambient temperature

7: 1.) Na, 2.) H₂O / 1.) 2-methoxyethanol, 115-120 deg C, 24 h, 2.) 100 deg C, 4 h

8: 18 percent / Et₃N, isobutyl chloroformate / dimethylsulfoxide / 19.5 h / Ambient temperature

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; ammonium hydroxide; water; sodium; sodium hydrogencarbonate; potassium carbonate; triethylamine; lithium diisopropyl amide; isobutyl chloroformate; In tetrahydrofuran; methanol; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00164a033

Reference yield:

: 123751-61-1
4-((E)-4-Methoxy-1-methyl-but-3-enyl)-benzoic acid

: 123751-78-0
10-methyl-5,10-dideazaminopterin diethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 27 percent / NaHCO₃ / dimethylformamide / 72 h / Ambient temperature

2: 95 percent / 1N HCl / acetic acid / 18 h / Ambient temperature

3: 94 percent / K₂CO₃ / 0.67 h / 60 °C

4: Et₃N / tetrahydrofuran / 1.) -20 deg C, 2.) RT, 15 h

5: 91 percent / conc. NH₄OH / methanol / 72 h / Ambient temperature

6: 1.) Na, 2.) H₂O / 1.) 2-methoxyethanol, 115-120 deg C, 24 h, 2.) 100 deg C, 4 h

7: 18 percent / Et₃N, isobutyl chloroformate / dimethylsulfoxide / 19.5 h / Ambient temperature

With hydrogenchloride; ammonium hydroxide; water; sodium; sodium hydrogencarbonate; potassium carbonate; triethylamine; isobutyl chloroformate; In tetrahydrofuran; methanol; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00164a033