Piperidine-3,4-dicarboxylic Acid

Base Information

Chemical Name:Piperidine-3,4-dicarboxylic Acid
CAS No.:577-58-2
Molecular Formula:C₇H₁₁NO₄
Molecular Weight:173.169
Hs Code.:
DSSTox Substance ID:DTXSID70875681

Synonyms:Piperidine-3,4-dicarboxylic Acid;577-58-2;SCHEMBL4187316;3,4-Piperidinedicarboxylic acid;Piperidine-3,4-dicarboxylicAcid;DTXSID70875681;AKOS023398862;EN300-126595;F8881-1623

Suppliers and Price of Piperidine-3,4-dicarboxylic Acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of Piperidine-3,4-dicarboxylic Acid

Chemical Property:

XLogP3:-3.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:173.06880783
Heavy Atom Count:12
Complexity:204

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CNCC(C1C(=O)O)C(=O)O

Technology Process of Piperidine-3,4-dicarboxylic Acid

There total 1 articles about Piperidine-3,4-dicarboxylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4664-08-8
cinchomeronic anhydride

: 577-58-2,87386-24-1
cis-piperidine-3,4-dicarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / acetic anhydride / Ambient temperature

2: 1.) 1M NaOH, H₂, 2.) 6 M HCl / 1.) Adams catalyst / 1.) water, 4 atm, 5 h, 2.) water, reflux, 1.5 h

3: 90 mg / NaIO₄ / H₂O / Ambient temperature

With hydrogenchloride; sodium hydroxide; sodium periodate; hydrogen; triethylamine; platinum(IV) oxide; In water; acetic anhydride;
DOI:10.1071/CH9831221

Reference yield:

: 577-58-2,87386-24-1
cis-piperidine-3,4-dicarboxylic acid

: (3S,4S)-1-Isopropyl-3-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonylmethyl]-piperidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: NaOH

2.1: 100 percent / Ac₂O / tetrahydrofuran

3.1: NaBH₄ / tetrahydrofuran

3.2: 44 percent / MeI; K₂CO₃ / dimethylformamide / 20 °C

4.1: 76 percent / NaH / dimethylformamide / 3 h / 80 °C

5.1: K₂CO₃ / dimethylformamide

6.1: K₂CO₃ / dimethylformamide / 80 °C

7.1: Oxone / methanol; H₂O

8.1: TFA / CH₂Cl₂

9.1: Na(OAc)3BH; NMM / tetrahydrofuran

With 4-methyl-morpholine; Oxone; sodium hydroxide; sodium tetrahydroborate; acetic anhydride; sodium tris(acetoxy)borohydride; sodium hydride; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.06.049

Reference yield:

: 577-58-2,87386-24-1
cis-piperidine-3,4-dicarboxylic acid

: (3S,4S)-4-(4-Hydroxy-phenylsulfanylmethyl)-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaOH

2.1: 100 percent / Ac₂O / tetrahydrofuran

3.1: NaBH₄ / tetrahydrofuran

3.2: 46 percent / MeI; K₂CO₃ / dimethylformamide / 20 °C

4.1: NaH / dimethylformamide / 3 h / 80 °C

5.1: K₂CO₃ / dimethylformamide

With sodium hydroxide; sodium tetrahydroborate; acetic anhydride; sodium hydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.06.049