3-(2-chloroethyl)-N-<2-ethyl>tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide

Base Information

• Chemical Name: 3-(2-chloroethyl)-N-<2-ethyl>tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
• CAS No.: 110971-89-6
• Molecular Formula: C₂₁H₂₉ClN₂O₆P₂
• Molecular Weight: 502.872
• Mol file: 110971-89-6.mol

Synonyms:

Chemical Property of 3-(2-chloroethyl)-N-<2-ethyl>tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-chloroethyl)-N-<2-ethyl>tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide

There total 2 articles about 3-(2-chloroethyl)-N-<2-ethyl>tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-aziridino-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin 2-oxide (29102-47-4) + phosphoric acid dibenzyl ester (1623-08-1) → 3-(2-chloroethyl)-N-<2-ethyl>tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide (110971-89-6)

Guidance literature:

In chloroform; for 1h; Ambient temperature;

DOI:10.1021/jm00396a036

Reference yield:

ilfosfamide (3778-73-2,84711-20-6) → 3-(2-chloroethyl)-N-<2-ethyl>tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide (110971-89-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / tetrahydrofuran

2: 74 percent / CHCl₃ / 1 h / Ambient temperature

With sodium hydride; In tetrahydrofuran; chloroform;

DOI:10.1021/jm00396a036

upstream raw materials:

2-aziridino-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin 2-oxide

phosphoric acid dibenzyl ester

ilfosfamide