C₂₃H₂₈F₂N₅O₇P

Base Information

• Chemical Name: C₂₃H₂₈F₂N₅O₇P
• CAS No.: 1350902-38-3
• Molecular Formula: C₂₃H₂₈F₂N₅O₇P
• Molecular Weight: 555.475
• Mol file: 1350902-38-3.mol

Synonyms:

Chemical Property of C₂₃H₂₈F₂N₅O₇P

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₃H₂₈F₂N₅O₇P

There total 3 articles about C₂₃H₂₈F₂N₅O₇P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

((2R,3R,4R)-3-(benzoyloxy)-4-fluoro-5-hydroxy-4-methyltetrahydrofuran-2-yl)methyl benzoate → C23H28F2N5O7P (1350902-38-3)

Guidance literature:

Multi-step reaction with 3 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 48 h / 20 °C

2: ammonium hydroxide / 1,4-dioxane / 20 h / 120 °C

3: 1-methyl-1H-imidazole / tetrahydrofuran / 14 h / 20 °C

With 1-methyl-1H-imidazole; ammonium hydroxide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; 1: Mitsunobu reaction;

DOI:10.1016/j.bmcl.2011.09.089

Reference yield:

((2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5-oxo-tetrahydrofuran-2-yl)methyl benzoate (874638-80-9,1033394-94-3) → C23H28F2N5O7P (1350902-38-3)

Guidance literature:

Multi-step reaction with 4 steps

1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 3 h / 0 °C

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 48 h / 20 °C

3: ammonium hydroxide / 1,4-dioxane / 20 h / 120 °C

4: 1-methyl-1H-imidazole / tetrahydrofuran / 14 h / 20 °C

With 1-methyl-1H-imidazole; ammonium hydroxide; lithium tri-t-butoxyaluminum hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; 2: Mitsunobu reaction;

DOI:10.1016/j.bmcl.2011.09.089

Reference yield:

C26H20ClF2N3O5 → C23H28F2N5O7P (1350902-38-3)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium hydroxide / 1,4-dioxane / 20 h / 120 °C

2: 1-methyl-1H-imidazole / tetrahydrofuran / 14 h / 20 °C

With 1-methyl-1H-imidazole; ammonium hydroxide; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1016/j.bmcl.2011.09.089

upstream raw materials:

((2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5-oxo-tetrahydrofuran-2-yl)methyl benzoate