Technology Process of methyl 2-(4-((N-(3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)-2-(dimethylamino)acetamido)methyl)phenyl)acetate mandelic acid salt
There total 8 articles about methyl 2-(4-((N-(3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)-2-(dimethylamino)acetamido)methyl)phenyl)acetate mandelic acid salt which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
acetonitrile;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: hydrogen / 1% platinum on charcoal / tetrahydrofuran / 72 h / 20 °C / 2250.23 Torr
2.1: 1-methyl-pyrrolidin-2-one / 73.5 h / 20 - 80 °C
3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 5 - 20 °C
4.1: ammonia; p-toluenesulfonyl chloride / dichloromethane; water / 2 h / 0 - 20 °C
5.1: trifluoroacetic acid / dichloromethane / 0.33 h
6.1: tetrahydrofuran / 16 h
6.2: 1 h
7.1: triethylamine / dichloromethane; N,N-dimethyl-formamide / 88 h
8.1: acetonitrile
With
ammonia; hydrogen; triethylamine; p-toluenesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid;
1% platinum on charcoal;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: nitric acid; propionic acid / 1.75 h / 125 °C / Heating / reflux
2.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 2.5 h / Heating / reflux
2.2: 0 °C
3.1: hydrogen / 1% platinum on charcoal / tetrahydrofuran / 72 h / 20 °C / 2250.23 Torr
4.1: 1-methyl-pyrrolidin-2-one / 73.5 h / 20 - 80 °C
5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 5 - 20 °C
6.1: ammonia; p-toluenesulfonyl chloride / dichloromethane; water / 2 h / 0 - 20 °C
7.1: trifluoroacetic acid / dichloromethane / 0.33 h
8.1: tetrahydrofuran / 16 h
8.2: 1 h
9.1: triethylamine / dichloromethane; N,N-dimethyl-formamide / 88 h
10.1: acetonitrile
With
thionyl chloride; ammonia; hydrogen; nitric acid; propionic acid; triethylamine; p-toluenesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid;
1% platinum on charcoal; N,N-dimethyl-formamide;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;