methyl 2-(4-((N-(3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)-2-(dimethylamino)acetamido)methyl)phenyl)acetate mandelic acid salt

Base Information

Chemical Name:methyl 2-(4-((N-(3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)-2-(dimethylamino)acetamido)methyl)phenyl)acetate mandelic acid salt
CAS No.:1080009-76-2
Molecular Formula:C₈H₈O₃*C₃₁H₄₀N₆O₃
Molecular Weight:696.847
Hs Code.:

methyl 2-(4-((N-(3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)-2-(dimethylamino)acetamido)methyl)phenyl)acetate mandelic acid salt

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Chemical Property of methyl 2-(4-((N-(3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)-2-(dimethylamino)acetamido)methyl)phenyl)acetate mandelic acid salt

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Technology Process of methyl 2-(4-((N-(3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)-2-(dimethylamino)acetamido)methyl)phenyl)acetate mandelic acid salt

There total 8 articles about methyl 2-(4-((N-(3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)-2-(dimethylamino)acetamido)methyl)phenyl)acetate mandelic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1080007-17-5
methyl 2-(4-((N-(3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)-2-(dimethylamino)acetamido)methyl)phenyl)acetate

: 611-71-2,611-72-3,17199-29-0,90-64-2
MANDELIC ACID

: 1080009-76-2
methyl 2-(4-((N-(3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)-2-(dimethylamino)acetamido)methyl)phenyl)acetate mandelic acid salt

Guidance literature:: In acetonitrile;

Reference yield:

: 860173-10-0
tert-butyl {3-[(3-nitroquinolin-4-yl)amino]propyl}carbamate

: 1080009-76-2
methyl 2-(4-((N-(3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)-2-(dimethylamino)acetamido)methyl)phenyl)acetate mandelic acid salt

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogen / 1% platinum on charcoal / tetrahydrofuran / 72 h / 20 °C / 2250.23 Torr

2.1: 1-methyl-pyrrolidin-2-one / 73.5 h / 20 - 80 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 5 - 20 °C

4.1: ammonia; p-toluenesulfonyl chloride / dichloromethane; water / 2 h / 0 - 20 °C

5.1: trifluoroacetic acid / dichloromethane / 0.33 h

6.1: tetrahydrofuran / 16 h

6.2: 1 h

7.1: triethylamine / dichloromethane; N,N-dimethyl-formamide / 88 h

8.1: acetonitrile

With ammonia; hydrogen; triethylamine; p-toluenesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; 1% platinum on charcoal; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 611-36-9
quinolin-4-ol

: 1080009-76-2
methyl 2-(4-((N-(3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)-2-(dimethylamino)acetamido)methyl)phenyl)acetate mandelic acid salt

Guidance literature:: Multi-step reaction with 10 steps

1.1: nitric acid; propionic acid / 1.75 h / 125 °C / Heating / reflux

2.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 2.5 h / Heating / reflux

2.2: 0 °C

3.1: hydrogen / 1% platinum on charcoal / tetrahydrofuran / 72 h / 20 °C / 2250.23 Torr

4.1: 1-methyl-pyrrolidin-2-one / 73.5 h / 20 - 80 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 5 - 20 °C

6.1: ammonia; p-toluenesulfonyl chloride / dichloromethane; water / 2 h / 0 - 20 °C

7.1: trifluoroacetic acid / dichloromethane / 0.33 h

8.1: tetrahydrofuran / 16 h

8.2: 1 h

9.1: triethylamine / dichloromethane; N,N-dimethyl-formamide / 88 h

10.1: acetonitrile

With thionyl chloride; ammonia; hydrogen; nitric acid; propionic acid; triethylamine; p-toluenesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; 1% platinum on charcoal; N,N-dimethyl-formamide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;