(1R,2S)-1-(4-fluorophenyl)-N¹,N²-bis((S)-1-phenylethyl)-butane-1,2-diamine

Base Information

Chemical Name:(1R,2S)-1-(4-fluorophenyl)-N¹,N²-bis((S)-1-phenylethyl)-butane-1,2-diamine
CAS No.:1434076-46-6
Molecular Formula:C₂₆H₃₁FN₂
Molecular Weight:390.544
Hs Code.:

(1R,2S)-1-(4-fluorophenyl)-N<SUP>1</SUP>,N<SUP>2</SUP>-bis((S)-1-phenylethyl)-butane-1,2-diamine

Synonyms:

Suppliers and Price of (1R,2S)-1-(4-fluorophenyl)-N¹,N²-bis((S)-1-phenylethyl)-butane-1,2-diamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2S)-1-(4-fluorophenyl)-N¹,N²-bis((S)-1-phenylethyl)-butane-1,2-diamine

Chemical Property:

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Technology Process of (1R,2S)-1-(4-fluorophenyl)-N¹,N²-bis((S)-1-phenylethyl)-butane-1,2-diamine

There total 5 articles about (1R,2S)-1-(4-fluorophenyl)-N¹,N²-bis((S)-1-phenylethyl)-butane-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 344332-43-0
C₁₀H₁₂FNO₃

: 1434076-46-6
(1R,2S)-1-(4-fluorophenyl)-N¹,N²-bis((S)-1-phenylethyl)-butane-1,2-diamine

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride / dichloromethane / 20 °C / Inert atmosphere; Cooling with ice

2: dihydrogen peroxide; sodium hydroxide / methanol / 0.17 h / Inert atmosphere; Cooling with ice

3: dichloromethane / 6 h / 20 °C / Inert atmosphere

4: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 16 h / Inert atmosphere

With dihydrogen peroxide; sodium tris(acetoxy)borohydride; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jo400501k

Reference yield:

: 437717-49-2
(E)-2-(4-fluorophenyl)-1-ethyl-1-nitroethylene

: 1434076-46-6
(1R,2S)-1-(4-fluorophenyl)-N¹,N²-bis((S)-1-phenylethyl)-butane-1,2-diamine

Guidance literature:: Multi-step reaction with 3 steps

1: dihydrogen peroxide; sodium hydroxide / methanol / 0.17 h / Inert atmosphere; Cooling with ice

2: dichloromethane / 6 h / 20 °C / Inert atmosphere

3: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 16 h / Inert atmosphere

With dihydrogen peroxide; sodium tris(acetoxy)borohydride; sodium hydroxide; In methanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jo400501k

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 1434076-46-6
(1R,2S)-1-(4-fluorophenyl)-N¹,N²-bis((S)-1-phenylethyl)-butane-1,2-diamine

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / 16 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride / dichloromethane / 20 °C / Inert atmosphere; Cooling with ice

3: dihydrogen peroxide; sodium hydroxide / methanol / 0.17 h / Inert atmosphere; Cooling with ice

4: dichloromethane / 6 h / 20 °C / Inert atmosphere

5: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 16 h / Inert atmosphere

With dihydrogen peroxide; sodium tris(acetoxy)borohydride; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jo400501k