C₄₅H₅₀N₈O₁₅S₂

Base Information

• Chemical Name: C₄₅H₅₀N₈O₁₅S₂
• CAS No.: 1380110-65-5
• Molecular Formula: C₄₅H₅₀N₈O₁₅S₂
• Molecular Weight: 1007.07
• Mol file: 1380110-65-5.mol

Synonyms:

Chemical Property of C₄₅H₅₀N₈O₁₅S₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₅H₅₀N₈O₁₅S₂

There total 14 articles about C₄₅H₅₀N₈O₁₅S₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(Z)-2-(((1-(2-((tert-butoxycarbonyl)-amino)thiazol-4-yl)-2-((2,5-dioxopyrrolidin-1-yl)oxy)-2-oxoethylidene)amino)oxy)-2-methylpropanoic acid tert-butyl ester (1229937-12-5) → C45H50N8O15S2 (1380110-65-5)

Guidance literature:

Multi-step reaction with 6 steps

1: triethylamine / acetonitrile / 0.08 h

2: triphenylphosphine; 1H-imidazole; iodine / dichloromethane / 15 h / 20 °C

3: triethylamine; tetrabutylammoniun azide / tetrahydrofuran; 2-methyltetrahydrofuran / 17 h / 20 - 35 °C

4: palladium 10% on activated carbon / ethanol / 4 h / 20 °C / 1551.49 Torr

5: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; sodium hydrogencarbonate / N,N-dimethyl-formamide / 20 °C

6: sulfur trioxide-N,N-dimethylformamide complex / N,N-dimethyl-formamide / 1 h / 20 °C

With 1H-imidazole; sulfur trioxide-N,N-dimethylformamide complex; palladium 10% on activated carbon; iodine; tetrabutylammoniun azide; sodium hydrogencarbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; triphenylphosphine; In tetrahydrofuran; 2-methyltetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm400560z

Reference yield:

tert-butyl 2-(((Z)-(1-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)-2-(((2S,3S)-2-(iodomethyl)-4-oxoazetidin-3-yl)amino)-2-oxoethylidene)amino)oxy)-2-methylpropanoate (1380109-68-1) → C45H50N8O15S2 (1380110-65-5)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine; tetrabutylammoniun azide / tetrahydrofuran; 2-methyltetrahydrofuran / 17 h / 20 - 35 °C

2: palladium 10% on activated carbon / ethanol / 4 h / 20 °C / 1551.49 Torr

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; sodium hydrogencarbonate / N,N-dimethyl-formamide / 20 °C

4: sulfur trioxide-N,N-dimethylformamide complex / N,N-dimethyl-formamide / 1 h / 20 °C

With sulfur trioxide-N,N-dimethylformamide complex; palladium 10% on activated carbon; tetrabutylammoniun azide; sodium hydrogencarbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In tetrahydrofuran; 2-methyltetrahydrofuran; ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm400560z

Reference yield:

tert-butyl 2-(((Z)-(1-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)-2-(((2S,3S)-2-(hydroxymethyl)-4-oxoazetidin-3-yl)amino)-2-oxoethylidene)amino)oxy)-2-methylpropanoate (1380109-67-0) → C45H50N8O15S2 (1380110-65-5)

Guidance literature:

Multi-step reaction with 5 steps

1: triphenylphosphine; 1H-imidazole; iodine / dichloromethane / 15 h / 20 °C

2: triethylamine; tetrabutylammoniun azide / tetrahydrofuran; 2-methyltetrahydrofuran / 17 h / 20 - 35 °C

3: palladium 10% on activated carbon / ethanol / 4 h / 20 °C / 1551.49 Torr

4: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; sodium hydrogencarbonate / N,N-dimethyl-formamide / 20 °C

5: sulfur trioxide-N,N-dimethylformamide complex / N,N-dimethyl-formamide / 1 h / 20 °C

With 1H-imidazole; sulfur trioxide-N,N-dimethylformamide complex; palladium 10% on activated carbon; iodine; tetrabutylammoniun azide; sodium hydrogencarbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; triphenylphosphine; In tetrahydrofuran; 2-methyltetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm400560z

upstream raw materials:

(Z)-2-(((1-(2-((tert-butoxycarbonyl)-amino)thiazol-4-yl)-2-((2,5-dioxopyrrolidin-1-yl)oxy)-2-oxoethylidene)amino)oxy)-2-methylpropanoic acid tert-butyl ester

tert-butyl 2-(((Z)-(1-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)-2-(((2S,3S)-2-(hydroxymethyl)-4-oxoazetidin-3-yl)amino)-2-oxoethylidene)amino)oxy)-2-methylpropanoate

tert-butyl 2-(((Z)-(1-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)-2-(((2S,3S)-2-(iodomethyl)-4-oxoazetidin-3-yl)amino)-2-oxoethylidene)amino)oxy)-2-methylpropanoate

tert-butyl 2-(((Z)-(2-(((2R,3S)-2-(azidomethyl)-4-oxoazetidin-3-yl)amino)-1-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)-2-oxoethylidene)amino)oxy)-2-methylpropanoate