S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-(2-diethylamino-acetyl)sulfoximide hydrochloride

Base Information

Chemical Name:S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-(2-diethylamino-acetyl)sulfoximide hydrochloride
CAS No.:1147096-25-0
Molecular Formula:C₂₆H₂₇Cl₂N₅O₄S*ClH
Molecular Weight:612.964
Hs Code.:

S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-(2-diethylamino-acetyl)sulfoximide hydrochloride

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Chemical Property of S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-(2-diethylamino-acetyl)sulfoximide hydrochloride

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Technology Process of S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-(2-diethylamino-acetyl)sulfoximide hydrochloride

There total 12 articles about S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-(2-diethylamino-acetyl)sulfoximide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 114129-35-0
methyl 4-(methylsulfinyl)benzoate

: 1147096-25-0
S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-(2-diethylamino-acetyl)sulfoximide hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1: sodium azide; sulfuric acid / chloroform / 15 h / -20 - 50 °C / Inert atmosphere

2: pyridine / dichloromethane; toluene / 3 h / 15 - 30 °C / Inert atmosphere

3: water; sodium hydroxide / tetrahydrofuran / 3 h / 25 - 30 °C

4: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 3 h / 10 - 30 °C / Inert atmosphere

5: tetrahydrofuran / 2 h / 10 - 30 °C / Inert atmosphere

6: sulfuric acid / 0 - 5 °C

7: triethylamine / tetrahydrofuran / 2 h / 0 - 30 °C

8: potassium iodide / N,N-dimethyl-formamide / 16 h / 25 - 30 °C

9: hydrogenchloride / dichloromethane; diethyl ether / 1 h / 25 - 30 °C

With pyridine; hydrogenchloride; sodium azide; oxalyl dichloride; sulfuric acid; water; triethylamine; N,N-dimethyl-formamide; potassium iodide; sodium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.ejmech.2012.10.005

Reference yield:

: 1147095-62-2,1147096-65-8
5-chloro-2-(4-(N-(2-chloroacetyl)-S-methylsulfonimidoyl)benzamido)-N-(5-chloropyridin-2-yl)benzamide

: 1147096-25-0
S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-(2-diethylamino-acetyl)sulfoximide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: potassium iodide / N,N-dimethyl-formamide / 16 h / 25 - 30 °C

2: hydrogenchloride / dichloromethane; diethyl ether / 1 h / 25 - 30 °C

With hydrogenchloride; potassium iodide; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.10.005

Reference yield:

: 2516-95-2
5-chloro-2-nitrobenzoic acid

: 1147096-25-0
S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-(2-diethylamino-acetyl)sulfoximide hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: pyridine; trichlorophosphate / acetonitrile / 1 h / 0 - 30 °C / Inert atmosphere

2: tin(II) chloride dihdyrate / ethyl acetate / 2 h / 25 - 30 °C

3: tetrahydrofuran / 2 h / 10 - 30 °C / Inert atmosphere

4: sulfuric acid / 0 - 5 °C

5: triethylamine / tetrahydrofuran / 2 h / 0 - 30 °C

6: potassium iodide / N,N-dimethyl-formamide / 16 h / 25 - 30 °C

7: hydrogenchloride / dichloromethane; diethyl ether / 1 h / 25 - 30 °C

With pyridine; hydrogenchloride; tin(II) chloride dihdyrate; sulfuric acid; triethylamine; potassium iodide; trichlorophosphate; In tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ejmech.2012.10.005