5-(4-Fluorophenyl)pyridin-2-OL

Base Information

Chemical Name:5-(4-Fluorophenyl)pyridin-2-OL
CAS No.:163563-23-3
Molecular Formula:C₁₁H₈FNO
Molecular Weight:189.189
Hs Code.:
DSSTox Substance ID:DTXSID60439938
Nikkaji Number:J666.780E
Wikidata:Q82256051

Synonyms:5-(4-fluorophenyl)-2-hydroxypyridine;FP2HP cpd

Suppliers and Price of 5-(4-Fluorophenyl)pyridin-2-OL

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Alichem
5-(4-Fluorophenyl)pyridin-2-ol
1g
$ 2952.90

Alichem
5-(4-Fluorophenyl)pyridin-2-ol
500mg
$ 1752.40

A1 Biochem Labs
5-(4-Fluorophenyl)pyridin-2-ol 95%
5 g
$ 1100.00

Total 1 raw suppliers

Chemical Property of 5-(4-Fluorophenyl)pyridin-2-OL

Chemical Property:

Boiling Point:387.3±42.0 °C(Predicted)
Density:1.245±0.06 g/cm3(Predicted)
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:189.058992041
Heavy Atom Count:14
Complexity:288

Purity/Quality:: 5-(4-Fluorophenyl)pyridin-2-ol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=CNC(=O)C=C2)F

Technology Process of 5-(4-Fluorophenyl)pyridin-2-OL

There total 3 articles about 5-(4-Fluorophenyl)pyridin-2-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 31695-66-6
2-hydroxy-5-(4-fluorophenyl)nicotinic acid

: 163563-23-3
5-(4-fluorophenyl)-2-hydroxypyridine

Guidance literature:: With quinoline; at 215 ℃; for 14h; Inert atmosphere;
DOI:10.1007/s10895-010-0692-3

Reference yield:

: 32669-61-7
2-hydroxy-5-(4-fluorophenyl)nicotinonitrile

: 163563-23-3
5-(4-fluorophenyl)-2-hydroxypyridine

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; acetic acid / 18 h / Reflux

2: quinoline / 14 h / 215 °C / Inert atmosphere

With quinoline; hydrogenchloride; acetic acid;
DOI:10.1007/s10895-010-0692-3

Reference yield:

: 405-50-5
p-Fluorophenylacetic acid

: 163563-23-3
5-(4-fluorophenyl)-2-hydroxypyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: Vilsmeier reagent / 7 h / 10 - 70 °C

1.2: 11.5 h / 20 °C / Reflux

2.1: hydrogenchloride; acetic acid / 18 h / Reflux

3.1: quinoline / 14 h / 215 °C / Inert atmosphere

With quinoline; hydrogenchloride; acetic acid;
DOI:10.1007/s10895-010-0692-3