4-Nitro-benzoic acid (1R,4S,4aR)-4,4a-dimethyl-7-oxo-1,2,3,4,4a,5,6,7-octahydro-naphthalen-1-yl ester

Base Information

• Chemical Name: 4-Nitro-benzoic acid (1R,4S,4aR)-4,4a-dimethyl-7-oxo-1,2,3,4,4a,5,6,7-octahydro-naphthalen-1-yl ester
• CAS No.: 852384-68-0
• Molecular Formula: C₁₉H₂₁NO₅
• Molecular Weight: 343.379
• Mol file: 852384-68-0.mol

Synonyms:

Chemical Property of 4-Nitro-benzoic acid (1R,4S,4aR)-4,4a-dimethyl-7-oxo-1,2,3,4,4a,5,6,7-octahydro-naphthalen-1-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Nitro-benzoic acid (1R,4S,4aR)-4,4a-dimethyl-7-oxo-1,2,3,4,4a,5,6,7-octahydro-naphthalen-1-yl ester

There total 4 articles about 4-Nitro-benzoic acid (1R,4S,4aR)-4,4a-dimethyl-7-oxo-1,2,3,4,4a,5,6,7-octahydro-naphthalen-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Nitro-benzoic acid (1S,4S,4aR)-4,4a-dimethyl-7-oxo-1,2,3,4,4a,5,6,7-octahydro-naphthalen-1-yl ester (852384-67-9) → 4-Nitro-benzoic acid (1R,4S,4aR)-4,4a-dimethyl-7-oxo-1,2,3,4,4a,5,6,7-octahydro-naphthalen-1-yl ester (852384-68-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 22 mg / LiOH*H₂O / methanol / 3 h

2: triphenylphosphine; diethyl azodicarboxylate / benzene / 18 h

With lithium hydroxide; triphenylphosphine; diethylazodicarboxylate; In methanol; benzene; 2: Mitsunobu reaction;

DOI:10.1021/jo0502450

Reference yield:

(4aR,5S)-4,4a,5,6,7,8-hexahydro-4a,5-dimethyl-2(3H)-naphthalenone (105088-15-1) → 4-Nitro-benzoic acid (1R,4S,4aR)-4,4a-dimethyl-7-oxo-1,2,3,4,4a,5,6,7-octahydro-naphthalen-1-yl ester (852384-68-0)

Guidance literature:

Multi-step reaction with 3 steps

1: TsOH; methanol / dimethylformamide / 24 h

2: 14 percent / Oxone(R); NaHCO₃ / tetrahydrofuran; H₂O / 5.5 h / 0 °C

3: triphenylphosphine; diethyl azodicarboxylate / benzene / 18 h

With methanol; oxone; sodium hydrogencarbonate; toluene-4-sulfonic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; water; N,N-dimethyl-formamide; benzene; 3: Mitsunobu reaction;

DOI:10.1021/jo0502450

Reference yield:

(1S,8aR)-1,2,3,7,8,8a-hexahydro-6-methoxy-1,8a-dimethylnaphthalene (150930-58-8) → 4-Nitro-benzoic acid (1R,4S,4aR)-4,4a-dimethyl-7-oxo-1,2,3,4,4a,5,6,7-octahydro-naphthalen-1-yl ester (852384-68-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 14 percent / Oxone(R); NaHCO₃ / tetrahydrofuran; H₂O / 5.5 h / 0 °C

2: triphenylphosphine; diethyl azodicarboxylate / benzene / 18 h

With oxone; sodium hydrogencarbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; water; benzene; 2: Mitsunobu reaction;

DOI:10.1021/jo0502450

upstream raw materials:

(4aR,5S,8S)-8-hydroxy-4a,5-dimethyl-4,4a,5,6,7,8-hexahydronaphthalen-2(3H)-one

4-nitro-benzoic acid

4-Nitro-benzoic acid (1S,4S,4aR)-4,4a-dimethyl-7-oxo-1,2,3,4,4a,5,6,7-octahydro-naphthalen-1-yl ester

(4aR,5S)-4,4a,5,6,7,8-hexahydro-4a,5-dimethyl-2(3H)-naphthalenone

Downstream raw materials:

4-Nitro-benzoic acid (1S,4S,4aR)-4,4a-dimethyl-7-oxo-1,2,3,4,4a,5,6,7-octahydro-naphthalen-1-yl ester