Technology Process of 1-chloro-4-((3R,4R)-4-methylhexa-1,5-dien-3-yl)benzene
There total 2 articles about 1-chloro-4-((3R,4R)-4-methylhexa-1,5-dien-3-yl)benzene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tris-(dibenzylideneacetone)dipalladium(0); (R)-(+)-2,2′-bis(di-2-furanylphosphino)-6,6′-dimethoxy-1,1′-biphenyl; cesium fluoride;
In
tetrahydrofuran;
at 22 ℃;
for 14h;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
Sealed vial;
DOI:10.1021/ja2075967
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium tetrahydroborate / methanol / Inert atmosphere
2: thionyl chloride / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
3: tris-(dibenzylideneacetone)dipalladium(0); (R)-(+)-2,2′-bis(di-2-furanylphosphino)-6,6′-dimethoxy-1,1′-biphenyl; cesium fluoride / tetrahydrofuran / 14 h / 22 °C / Inert atmosphere; Sealed vial
With
sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium(0); thionyl chloride; (R)-(+)-2,2′-bis(di-2-furanylphosphino)-6,6′-dimethoxy-1,1′-biphenyl; cesium fluoride;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ja2075967