tri--tert-butyl 2,2',2''-(10--(2--(2--((((9H--fluoren-9-yl)methoxy)carbonyl)amino)-3--(4-hydroxy--3,5--diiodophenyl)propanamido)--3-(((S)-1-methoxy-1-oxopropan-2-yl)amino)-3-oxopropyl)-1,4,7,10-tetraazacyclododecane-1,4,7--triyl)triacetate

Base Information

Chemical Name:tri--tert-butyl 2,2',2''-(10--(2--(2--((((9H--fluoren-9-yl)methoxy)carbonyl)amino)-3--(4-hydroxy--3,5--diiodophenyl)propanamido)--3-(((S)-1-methoxy-1-oxopropan-2-yl)amino)-3-oxopropyl)-1,4,7,10-tetraazacyclododecane-1,4,7--triyl)triacetate
CAS No.:1423015-77-3
Molecular Formula:C₅₆H₇₇I₂N₇O₁₃
Molecular Weight:1310.08
Hs Code.:

tri--tert-butyl 2,2',2''-(10--(2--(2--((((9H--fluoren-9-yl)methoxy)carbonyl)amino)-3--(4-hydroxy--3,5--diiodophenyl)propanamido)--3-(((S)-1-methoxy-1-oxopropan-2-yl)amino)-3-oxopropyl)-1,4,7,10-tetraazacyclododecane-1,4,7--triyl)triacetate

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Chemical Property of tri--tert-butyl 2,2',2''-(10--(2--(2--((((9H--fluoren-9-yl)methoxy)carbonyl)amino)-3--(4-hydroxy--3,5--diiodophenyl)propanamido)--3-(((S)-1-methoxy-1-oxopropan-2-yl)amino)-3-oxopropyl)-1,4,7,10-tetraazacyclododecane-1,4,7--triyl)triacetate

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Technology Process of tri--tert-butyl 2,2',2''-(10--(2--(2--((((9H--fluoren-9-yl)methoxy)carbonyl)amino)-3--(4-hydroxy--3,5--diiodophenyl)propanamido)--3-(((S)-1-methoxy-1-oxopropan-2-yl)amino)-3-oxopropyl)-1,4,7,10-tetraazacyclododecane-1,4,7--triyl)triacetate

There total 3 articles about tri--tert-butyl 2,2',2''-(10--(2--(2--((((9H--fluoren-9-yl)methoxy)carbonyl)amino)-3--(4-hydroxy--3,5--diiodophenyl)propanamido)--3-(((S)-1-methoxy-1-oxopropan-2-yl)amino)-3-oxopropyl)-1,4,7,10-tetraazacyclododecane-1,4,7--triyl)triacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1423015-76-2
tri--tert-butyl 2,2',2''--(10--(2--amino--3--((2-methoxy--2--oxoethyl)amino)--3--oxopropyl)--1,4,7,10--tetraazacyclododecane--1,4,7--triyl)triacetate

: 103213-31-6,212651-51-9
(S)--2--((((9H-fluoren-9--yl)methoxy)carbonyl)amino)--3-(4-hydroxy-3,5diiodophenyl)propanoic acid

: 1423015-77-3
tri--tert-butyl 2,2',2''-(10--(2--(2--((((9H--fluoren-9-yl)methoxy)carbonyl)amino)-3--(4-hydroxy--3,5--diiodophenyl)propanamido)--3-(((S)-1-methoxy-1-oxopropan-2-yl)amino)-3-oxopropyl)-1,4,7,10-tetraazacyclododecane-1,4,7--triyl)triacetate

Guidance literature:: (S)--2--((((9H-fluoren-9--yl)methoxy)carbonyl)amino)--3-(4-hydroxy-3,5diiodophenyl)propanoic acid; With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; HATU; In N,N-dimethyl-formamide; for 0.0833333h;

tri--tert-butyl 2,2',2''--(10--(2--amino--3--((2-methoxy--2--oxoethyl)amino)--3--oxopropyl)--1,4,7,10--tetraazacyclododecane--1,4,7--triyl)triacetate; In N,N-dimethyl-formamide; at 20 ℃; for 14h;
DOI:10.1021/jm4000177

Reference yield:

: 1423015-89-7
C₄₄H₆₅N₅O₁₀

: 1423015-77-3
tri--tert-butyl 2,2',2''-(10--(2--(2--((((9H--fluoren-9-yl)methoxy)carbonyl)amino)-3--(4-hydroxy--3,5--diiodophenyl)propanamido)--3-(((S)-1-methoxy-1-oxopropan-2-yl)amino)-3-oxopropyl)-1,4,7,10-tetraazacyclododecane-1,4,7--triyl)triacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: HATU; 1-hydroxy-7-aza-benzotriazole; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.08 h

1.2: 14 h / 20 °C

2.1: solid--support--piperazine / N,N-dimethyl-formamide / 14 h / 20 °C

3.1: HATU; 1-hydroxy-7-aza-benzotriazole; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.08 h

3.2: 14 h / 20 °C

With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; HATU; In N,N-dimethyl-formamide;
DOI:10.1021/jm4000177

Reference yield:

: 1423015-75-1
tri--tert--butyl 2,2',2''--(10--(2--((((9H--fluoren--9--yl)methoxy)carbonyl)amino)--3--((2--methoxy--2--oxoethyl)amino)--3--oxopropyl)--1,4,7,10-tetraazacyclododecane--1,4,7--triyl)triacetate

: 1423015-77-3
tri--tert-butyl 2,2',2''-(10--(2--(2--((((9H--fluoren-9-yl)methoxy)carbonyl)amino)-3--(4-hydroxy--3,5--diiodophenyl)propanamido)--3-(((S)-1-methoxy-1-oxopropan-2-yl)amino)-3-oxopropyl)-1,4,7,10-tetraazacyclododecane-1,4,7--triyl)triacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: solid--support--piperazine / N,N-dimethyl-formamide / 14 h / 20 °C

2.1: HATU; 1-hydroxy-7-aza-benzotriazole; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.08 h

2.2: 14 h / 20 °C

With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; HATU; In N,N-dimethyl-formamide;
DOI:10.1021/jm4000177