2-(hydroxyphenylmethyl)-1,4,5-trimethoxynaphthalene

Base Information

Chemical Name:2-(hydroxyphenylmethyl)-1,4,5-trimethoxynaphthalene
CAS No.:107941-26-4
Molecular Formula:C₂₀H₂₀O₄
Molecular Weight:324.376
Hs Code.:

Synonyms:

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Chemical Property of 2-(hydroxyphenylmethyl)-1,4,5-trimethoxynaphthalene

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Technology Process of 2-(hydroxyphenylmethyl)-1,4,5-trimethoxynaphthalene

There total 5 articles about 2-(hydroxyphenylmethyl)-1,4,5-trimethoxynaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 69008-03-3
2-bromo-5-hydroxy-[1,4]naphthoquinone

: 107941-26-4
2-(hydroxyphenylmethyl)-1,4,5-trimethoxynaphthalene

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / Ag₂O / CH₂Cl₂ / 20 h / Ambient temperature

2: 90 percent / sodium dithionate / diethyl ether; H₂O / 0.17 h

3: 92 percent / K₂CO₃ / acetone / 24 h / Heating

4: 1.) tert-butyllithium / 1.) THF, pentane, -78 deg C, 15 min, 2.) -78 deg C, 1 h

With sodium dithionate; tert.-butyl lithium; potassium carbonate; silver(l) oxide; In diethyl ether; dichloromethane; water; acetone;
DOI:10.1021/jo00386a002

Reference yield:

: 69833-09-6
2-bromo-5-methoxy-[1,4]naphthoquinone

: 107941-26-4
2-(hydroxyphenylmethyl)-1,4,5-trimethoxynaphthalene

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / sodium dithionate / diethyl ether; H₂O / 0.17 h

2: 92 percent / K₂CO₃ / acetone / 24 h / Heating

3: 1.) tert-butyllithium / 1.) THF, pentane, -78 deg C, 15 min, 2.) -78 deg C, 1 h

With sodium dithionate; tert.-butyl lithium; potassium carbonate; In diethyl ether; water; acetone;
DOI:10.1021/jo00386a002

Reference yield:

: 77189-69-6
5-acetoxy-2-bromo-1,4-naphthoquinone

: 107941-26-4
2-(hydroxyphenylmethyl)-1,4,5-trimethoxynaphthalene

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / 3N H₂SO₄ / ethanol / 1.5 h / Heating

2: 98 percent / Ag₂O / CH₂Cl₂ / 20 h / Ambient temperature

3: 90 percent / sodium dithionate / diethyl ether; H₂O / 0.17 h

4: 92 percent / K₂CO₃ / acetone / 24 h / Heating

5: 1.) tert-butyllithium / 1.) THF, pentane, -78 deg C, 15 min, 2.) -78 deg C, 1 h

With sodium dithionate; sulfuric acid; tert.-butyl lithium; potassium carbonate; silver(l) oxide; In diethyl ether; ethanol; dichloromethane; water; acetone;
DOI:10.1021/jo00386a002