3-ethynylpyridine-4-carbaldehyde

Base Information

• Chemical Name: 3-ethynylpyridine-4-carbaldehyde
• CAS No.: 1196153-32-8
• Molecular Formula: C₈H₅NO
• Molecular Weight: 131.134
• Mol file: 1196153-32-8.mol

Synonyms:

Chemical Property of 3-ethynylpyridine-4-carbaldehyde

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

3-Ethynylisonicotinaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-ethynylpyridine-4-carbaldehyde

There total 2 articles about 3-ethynylpyridine-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3-(trimethylsilylethynyl)pyridine-4-carboxaldehyde (222167-62-6) → 3-ethynylpyridine-4-carbaldehyde (1196153-32-8)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 0.0833333h;

DOI:10.1002/ejoc.202001016

Reference yield:

3-bromo-pyridine-4-carbaldehyde (70201-43-3) → 3-ethynylpyridine-4-carbaldehyde (1196153-32-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 0.08 h / 20 °C / Inert atmosphere

1.2: 5 h / 80 °C / Inert atmosphere

2.1: potassium carbonate; methanol / 5 h / 20 °C

With methanol; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; triethylamine; In tetrahydrofuran;

DOI:10.1002/cjoc.201201118

Reference yield: 62.0%

3-ethynylpyridine-4-carbaldehyde (1196153-32-8) → C14H11NO

Guidance literature:

In tetrahydrofuran; at -78 - 20 ℃; for 1h;

DOI:10.1002/ejoc.202001016

upstream raw materials:

3-(trimethylsilylethynyl)pyridine-4-carboxaldehyde

3-bromo-pyridine-4-carbaldehyde