rel-(4aR,6R,7aR)-7-hydroxy-7-phenylcyclopenta<1,3>dioxane

Base Information

Chemical Name:rel-(4aR,6R,7aR)-7-hydroxy-7-phenylcyclopenta<1,3>dioxane
CAS No.:147102-71-4
Molecular Formula:C₁₃H₁₆O₃
Molecular Weight:220.268
Hs Code.:

rel-(4aR,6R,7aR)-7-hydroxy-7-phenylcyclopenta<d><1,3>dioxane

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of rel-(4aR,6R,7aR)-7-hydroxy-7-phenylcyclopenta<1,3>dioxane

Chemical Property:

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Technology Process of rel-(4aR,6R,7aR)-7-hydroxy-7-phenylcyclopenta<1,3>dioxane

There total 3 articles about rel-(4aR,6R,7aR)-7-hydroxy-7-phenylcyclopenta<1,3>dioxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: phenylmagnesium bromide

: 147102-67-8
cis-(H-4a,H-7a)-7-ketocyclopenta<1,3>dioxane

: 147102-71-4
rel-(4aR,6R,7aR)-7-hydroxy-7-phenylcyclopenta<1,3>dioxane

Guidance literature:: In diethyl ether; for 3h; Heating;
DOI:10.1002/mrc.1260310113

Reference yield:

: 147102-73-6
cis-(H-4a,H-7a)-7-hydroxycyclopenta<1,3>dioxane

: 147102-71-4
rel-(4aR,6R,7aR)-7-hydroxy-7-phenylcyclopenta<1,3>dioxane

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / CrO₃, H₂SO₄, H₂O / diethyl ether / 5 h

2: 89 percent / diethyl ether / 3 h / Heating

With chromium(VI) oxide; sulfuric acid; water; In diethyl ether;
DOI:10.1002/mrc.1260310113

Reference yield:

: 148619-83-4
cis-(H-4a,H-7a)-4,4a,5,7a-tetrahydro-2H-cyclopenta<1,3>dioxin

: 147102-71-4
rel-(4aR,6R,7aR)-7-hydroxy-7-phenylcyclopenta<1,3>dioxane

Guidance literature:: Multi-step reaction with 3 steps

1: 1) BH₃-THF complex, 2) 30percent H₂O₂, 2.5 M aq. NaOH / 1) THF, -10 deg C, 1 h, 2) -5 deg C, 0.5 h

2: 80 percent / CrO₃, H₂SO₄, H₂O / diethyl ether / 5 h

3: 89 percent / diethyl ether / 3 h / Heating

With chromium(VI) oxide; sodium hydroxide; borane-THF; sulfuric acid; water; dihydrogen peroxide; In diethyl ether;
DOI:10.1002/mrc.1260310113