Technology Process of C12H18O3
There total 4 articles about C12H18O3 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
tert-butyl ((E)-3-(4-methoxyphenyl)-but-2-en-1-yl) carbonate; 2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;
With
tris-(dibenzylideneacetone)dipalladium(0); (R)-(+)-2,2′-bis(di-2-furanylphosphino)-6,6′-dimethoxy-1,1′-biphenyl; cesium fluoride;
In
tetrahydrofuran; water;
at 80 ℃;
for 12h;
Inert atmosphere;
With
ozone;
In
methanol; dichloromethane;
at -78 ℃;
With
sodium tetrahydroborate;
In
methanol; dichloromethane;
at -78 - 20 ℃;
Inert atmosphere;
DOI:10.1021/ja2039248
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: silica gel
2.1: tris-(dibenzylideneacetone)dipalladium(0); (R)-(+)-2,2′-bis(di-2-furanylphosphino)-6,6′-dimethoxy-1,1′-biphenyl; cesium fluoride / tetrahydrofuran; water / 12 h / 80 °C / Inert atmosphere
2.2: -78 °C
2.3: -78 - 20 °C / Inert atmosphere
With
tris-(dibenzylideneacetone)dipalladium(0); (R)-(+)-2,2′-bis(di-2-furanylphosphino)-6,6′-dimethoxy-1,1′-biphenyl; silica gel; cesium fluoride;
In
tetrahydrofuran; water;
DOI:10.1021/ja2039248
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C / Inert atmosphere; Cooling with acetone-dry ice
1.2: -78 - 4 °C / Inert atmosphere
2.1: silica gel
3.1: tris-(dibenzylideneacetone)dipalladium(0); (R)-(+)-2,2′-bis(di-2-furanylphosphino)-6,6′-dimethoxy-1,1′-biphenyl; cesium fluoride / tetrahydrofuran; water / 12 h / 80 °C / Inert atmosphere
3.2: -78 °C
3.3: -78 - 20 °C / Inert atmosphere
With
tris-(dibenzylideneacetone)dipalladium(0); n-butyllithium; (R)-(+)-2,2′-bis(di-2-furanylphosphino)-6,6′-dimethoxy-1,1′-biphenyl; silica gel; cesium fluoride;
In
tetrahydrofuran; hexane; water;
DOI:10.1021/ja2039248
