5-(4-{4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-4-methoxycarbonyl-butylcarbamoyl)-pyridine-2-carboxylic acid methyl ester

Base Information

• Chemical Name: 5-(4-{4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-4-methoxycarbonyl-butylcarbamoyl)-pyridine-2-carboxylic acid methyl ester
• CAS No.: 1053735-50-4
• Molecular Formula: C₂₉H₃₂N₈O₆
• Molecular Weight: 588.623
• Mol file: 1053735-50-4.mol

Synonyms:

Chemical Property of 5-(4-{4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-4-methoxycarbonyl-butylcarbamoyl)-pyridine-2-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-{4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-4-methoxycarbonyl-butylcarbamoyl)-pyridine-2-carboxylic acid methyl ester

There total 4 articles about 5-(4-{4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-4-methoxycarbonyl-butylcarbamoyl)-pyridine-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-(methoxycarbonyl)nicotinic acid (17874-76-9) + 5-amino-2-{4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-pentanoic acid methyl ester; hydrochloride → 5-(4-{4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-4-methoxycarbonyl-butylcarbamoyl)-pyridine-2-carboxylic acid methyl ester (1053735-50-4)

Guidance literature:

With triethylamine; diethyl dicarbonate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1248/cpb.48.1270

Reference yield:

methyl Nδ-(tert-butoxycarbonyl)-L-ornithinate (51186-41-5) → 5-(4-{4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-4-methoxycarbonyl-butylcarbamoyl)-pyridine-2-carboxylic acid methyl ester (1053735-50-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / Et₃N; DEPC / dimethylformamide / 1 h / 20 °C

2: HCl / ethyl acetate / 0.33 h / 20 °C

3: DEPC; Et₃N / dimethylformamide / 20 °C

With hydrogenchloride; triethylamine; diethyl dicarbonate; In ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1248/cpb.48.1270

Reference yield:

4-<2-(2,4-Diaminopyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoic acid (149010-53-7) → 5-(4-{4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-4-methoxycarbonyl-butylcarbamoyl)-pyridine-2-carboxylic acid methyl ester (1053735-50-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / Et₃N; DEPC / dimethylformamide / 1 h / 20 °C

2: HCl / ethyl acetate / 0.33 h / 20 °C

3: DEPC; Et₃N / dimethylformamide / 20 °C

With hydrogenchloride; triethylamine; diethyl dicarbonate; In ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1248/cpb.48.1270

upstream raw materials:

6-(methoxycarbonyl)nicotinic acid

methyl N^δ-(tert-butoxycarbonyl)-L-ornithinate

4-<2-(2,4-Diaminopyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoic acid

methyl N^δ-(tert-butoxycarbonyl)-N^α-[4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-ornithinate