Technology Process of threo-(1R,2R)-1-[3-methoxy-4-(methoxymethoxy)phenyl]-1-(2,3,4,5-tetrahydropyran-2-yloxy)-2-propanol
There total 7 articles about threo-(1R,2R)-1-[3-methoxy-4-(methoxymethoxy)phenyl]-1-(2,3,4,5-tetrahydropyran-2-yloxy)-2-propanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: benzene / Reflux
2: lithium aluminium tetrahydride; aluminum (III) chloride / tetrahydrofuran
3: AD-mix-β; methanesulfonamide; water / tert-butyl alcohol / 0 °C
4: pyridine / dichloromethane / 20 °C
5: potassium carbonate / methanol / 5 h / 20 °C
6: pyridinium p-toluenesulfonate / dichloromethane / 20 °C
7: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / 20 °C
8: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C
9: potassium carbonate / acetone / 3 h / 20 °C / Inert atmosphere
With
pyridine; aluminum (III) chloride; lithium aluminium tetrahydride; methanesulfonamide; AD-mix-β; palladium 10% on activated carbon; water; hydrogen; pyridinium p-toluenesulfonate; potassium carbonate;
In
tetrahydrofuran; methanol; dichloromethane; acetone; tert-butyl alcohol; benzene;
1: Wittig reaction;
DOI:10.1007/s00706-010-0420-3
- Guidance literature:
-
Multi-step reaction with 2 steps
1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C
2: potassium carbonate / acetone / 3 h / 20 °C / Inert atmosphere
With
palladium 10% on activated carbon; hydrogen; potassium carbonate;
In
methanol; acetone;
DOI:10.1007/s00706-010-0420-3
