1,14-dihydroxyherbertene

Base Information

• Chemical Name: 1,14-dihydroxyherbertene
• CAS No.: 86996-96-5
• Molecular Formula: C₁₅H₂₂O₂
• Molecular Weight: 234.338
• Mol file: 86996-96-5.mol

Synonyms:

Chemical Property of 1,14-dihydroxyherbertene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,14-dihydroxyherbertene

There total 1 articles about 1,14-dihydroxyherbertene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(-)-herbertenolide (86996-94-3) → 1,14-dihydroxyherbertene (86996-96-5)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 2h; ice-bath;

Reference yield:

1,14-dihydroxyherbertene (86996-96-5) → (S)-5-methyl-3-(1,2,2-trimethylcyclopentyl)benzene-1,2-diol (86996-95-4)

Guidance literature:

Multi-step reaction with 5 steps

1: (PhO)3PCH₃I / hexamethylphosphoric acid triamide

2: AlCl₃

3: Ra-Ni / ethanol

4: 1.) (PhCOO)2; 2.) pyridine / 1.) benzene

5: LAH / diethyl ether

With pyridine; lithium aluminium tetrahydride; aluminium trichloride; methyltriphenoxyphosphonium iodide; dibenzoyl peroxide; Ra-Ni; In N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; ethanol;

DOI:10.1246/cl.1983.1041

Reference yield:

1,14-dihydroxyherbertene (86996-96-5) → 4-methyl-2-[(1S)-1,2,2-trimethylcyclopentyl]phenol (81784-10-3)

Guidance literature:

Multi-step reaction with 3 steps

1: (PhO)3PCH₃I / hexamethylphosphoric acid triamide

2: AlCl₃

3: Ra-Ni / ethanol

With aluminium trichloride; methyltriphenoxyphosphonium iodide; Ra-Ni; In N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol;

DOI:10.1246/cl.1983.1041

upstream raw materials:

(-)-herbertenolide

Downstream raw materials:

14-hydroxy-1-methoxyherbertene

4-methyl-2-[(1S)-1,2,2-trimethylcyclopentyl]phenol

(S)-5-methyl-3-(1,2,2-trimethylcyclopentyl)benzene-1,2-diol

14-ethylthio-1-hydroxyherbertene