N-[(Benzyloxy)carbonyl]-L-leucine pentachlorophenyl ester

Base Information

• Chemical Name: N-[(Benzyloxy)carbonyl]-L-leucine pentachlorophenyl ester
• CAS No.: 13758-71-9
• Molecular Formula: C₂₀H₁₈Cl₅NO₄
• Molecular Weight: 513.632
• Mol file: 13758-71-9.mol

Synonyms:(S)-2-Benzyloxycarbonylamino-4-methyl-pentanoic acid pentachlorophenyl ester;

Chemical Property of N-[(Benzyloxy)carbonyl]-L-leucine pentachlorophenyl ester

Chemical Property:

• PSA: 64.63000
• LogP: 7.59100

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-[(Benzyloxy)carbonyl]-L-leucine pentachlorophenyl ester

There total 1 articles about N-[(Benzyloxy)carbonyl]-L-leucine pentachlorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ Z-Leu-OPCP (13758-71-9)

Guidance literature:

DOI:10.1248/cpb.16.929

Reference yield:

Z-Leu-OPCP (13758-71-9) + (S)-2-(2-{(R)-5-Amino-2-[(S)-2-tert-butoxycarbonylamino-3-(4-tert-butoxycarbonyloxy-phenyl)-propionylamino]-pentanoylamino}-acetylamino)-3-phenyl-propionic acid (210777-41-6) → (S)-2-(2-{(R)-5-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-2-[(S)-2-tert-butoxycarbonylamino-3-(4-tert-butoxycarbonyloxy-phenyl)-propionylamino]-pentanoylamino}-acetylamino)-3-phenyl-propionic acid (210777-23-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; Yield given;

DOI:10.1016/S0223-5234(98)80060-3

Reference yield:

Z-Leu-OPCP (13758-71-9) + (S)-2-amino-3-methylbutanamide hydrobromide (33529-85-0) → N-(N-benzyloxycarbonyl-L-leucyl)-L-valine amide (14611-15-5)

Guidance literature:

With N-ethylmorpholine;; benzotriazol-1-ol; In N,N-dimethyl-formamide;

Downstream raw materials:

N-(N-benzyloxycarbonyl-L-leucyl)-L-valine amide

(S)-2-(2-{(R)-5-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-2-[(S)-2-tert-butoxycarbonylamino-3-(4-tert-butoxycarbonyloxy-phenyl)-propionylamino]-pentanoylamino}-acetylamino)-3-phenyl-propionic acid

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