Bisindolylmaleimide II

Base Information

• Chemical Name: Bisindolylmaleimide II
• CAS No.: 137592-45-1
• Molecular Formula: C27H26N4O2
• Molecular Weight: 438.52100
• DSSTox Substance ID: DTXSID001314226
• Nikkaji Number: J1.032.417C
• ChEMBL ID: CHEMBL218328
• Mol file: 137592-45-1.mol

Synonyms:2-(1-(2-(1-methylpyrrolidino)ethyl)-1H-indol-3-yl)maleimide;bisindolylmaleimide II

Chemical Property of Bisindolylmaleimide II

Chemical Property:

• PSA: 70.13000
• LogP: 4.44080
• Storage Temp.: −20°C
• Solubility.: DMSO: soluble
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 438.20557608
• Heavy Atom Count: 33
• Complexity: 825

Purity/Quality:

98% ^*data from raw suppliers

Bisindolylmaleimide II ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCCC1CCN2C=C(C3=CC=CC=C32)C4=C(C(=O)NC4=O)C5=CNC6=CC=CC=C65
• Uses: Bisindolylmaleimide II, is a potent ATP-competitive protein kinase C (PKC) inhibitor. In addition it inhibits PDK1 (IC50 = 14 μM), an important kinase in the insulin signaling pathway, and PKA (IC50 = 2.94 μM).