N-(3-((4S,6S)-2-benzamido-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-4-(difluoromethyl)piperidine-1-carboxamide

Base Information

• Chemical Name: N-(3-((4S,6S)-2-benzamido-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-4-(difluoromethyl)piperidine-1-carboxamide
• CAS No.: 1624605-96-4
• Molecular Formula: C₂₆H₂₆F₆N₄O₃
• Molecular Weight: 556.508

Synonyms:

Chemical Property of N-(3-((4S,6S)-2-benzamido-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-4-(difluoromethyl)piperidine-1-carboxamide

Chemical Property:

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Safty Information:

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Useful:

Technology Process of N-(3-((4S,6S)-2-benzamido-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-4-(difluoromethyl)piperidine-1-carboxamide

There total 4 articles about N-(3-((4S,6S)-2-benzamido-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-4-(difluoromethyl)piperidine-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(difluoromethyl)piperidine → N-(3-((4S,6S)-2-benzamido-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-4-(difluoromethyl)piperidine-1-carboxamide (1624605-96-4)

Guidance literature:

Reference yield:

1,2,3,6-tetrahydropyridine (694-05-3) → N-(3-((4S,6S)-2-benzamido-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-4-(difluoromethyl)piperidine-1-carboxamide (1624605-96-4)

Guidance literature:

Reference yield:

benzyl 4-(difluoromethyl)piperidine-1-carboxylate (1624605-95-3) → N-(3-((4S,6S)-2-benzamido-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-4-(difluoromethyl)piperidine-1-carboxamide (1624605-96-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / ethanol

With hydrogen; In ethanol;

upstream raw materials:

N-(benzyloxycarbonyl)piperidine-4-carboxaldehyde

benzyl 4-(difluoromethyl)piperidine-1-carboxylate

1,2,3,6-tetrahydropyridine

Downstream raw materials:

N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5,6-dihydropyridine-1(2H)-carboxamide

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