tetrabutylammonium 2-fluoromethyl-4-methyl-benzenesulfonate

Base Information

• Chemical Name: tetrabutylammonium 2-fluoromethyl-4-methyl-benzenesulfonate
• CAS No.: 1344707-89-6
• Molecular Formula: C₈H₈FO₃S*C₁₆H₃₆N
• Molecular Weight: 445.683
• Mol file: 1344707-89-6.mol

Synonyms:

Chemical Property of tetrabutylammonium 2-fluoromethyl-4-methyl-benzenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tetrabutylammonium 2-fluoromethyl-4-methyl-benzenesulfonate

There total 5 articles about tetrabutylammonium 2-fluoromethyl-4-methyl-benzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-t-butyl-p-toluenesulfonamide (2849-81-2) → tetrabutylammonium 2-fluoromethyl-4-methyl-benzenesulfonate (1344707-89-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran / 0.75 h / -78 - -20 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

1.3: 0 - 20 °C

2.1: toluene-4-sulfonic acid / toluene / 1 h / Reflux

2.2: Reflux

3.1: sodium hydride / tetrahydrofuran / 20 °C

4.1: [D₃]acetonitrile / 24 h / 20 °C / Inert atmosphere

With n-butyllithium; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; [D₃]acetonitrile; toluene;

DOI:10.1039/c1cc14435a

Reference yield:

N-tert-butyl-2-hydroxymethyl-4-methylbenzenesulfonamide (304649-53-4) → tetrabutylammonium 2-fluoromethyl-4-methyl-benzenesulfonate (1344707-89-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid / toluene / 1 h / Reflux

1.2: Reflux

2.1: sodium hydride / tetrahydrofuran / 20 °C

3.1: [D₃]acetonitrile / 24 h / 20 °C / Inert atmosphere

With sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; [D₃]acetonitrile; toluene;

DOI:10.1039/c1cc14435a

Reference yield:

[2-(2,5-dimethylpyrrole-1-sulfonyl)-5-methylphenyl]methanol (1344708-05-9) → tetrabutylammonium 2-fluoromethyl-4-methyl-benzenesulfonate (1344707-89-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran / 20 °C

2: [D₃]acetonitrile / 24 h / 20 °C / Inert atmosphere

With sodium hydride; In tetrahydrofuran; [D₃]acetonitrile;

DOI:10.1039/c1cc14435a

upstream raw materials:

N-tert-butyl-2-hydroxymethyl-4-methylbenzenesulfonamide

[2-(2,5-dimethylpyrrole-1-sulfonyl)-5-methylphenyl]methanol

N-t-butyl-p-toluenesulfonamide

tetrabutyl ammonium fluoride