4-[3-(4-{1-[(tert-butoxycarbonyl)amino]cyclobutyl}phenyl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-2-yl]phenyl trifluoromethane sulfonate

Base Information

Chemical Name:4-[3-(4-{1-[(tert-butoxycarbonyl)amino]cyclobutyl}phenyl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-2-yl]phenyl trifluoromethane sulfonate
CAS No.:1374263-66-7
Molecular Formula:C₃₆H₃₂F₃N₅O₅S
Molecular Weight:703.742
Hs Code.:

4-[3-(4-{1-[(tert-butoxycarbonyl)amino]cyclobutyl}phenyl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-2-yl]phenyl trifluoromethane sulfonate

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Chemical Property of 4-[3-(4-{1-[(tert-butoxycarbonyl)amino]cyclobutyl}phenyl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-2-yl]phenyl trifluoromethane sulfonate

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Technology Process of 4-[3-(4-{1-[(tert-butoxycarbonyl)amino]cyclobutyl}phenyl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-2-yl]phenyl trifluoromethane sulfonate

There total 8 articles about 4-[3-(4-{1-[(tert-butoxycarbonyl)amino]cyclobutyl}phenyl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-2-yl]phenyl trifluoromethane sulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 885-70-1
5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one

: 1374263-66-7
4-[3-(4-{1-[(tert-butoxycarbonyl)amino]cyclobutyl}phenyl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-2-yl]phenyl trifluoromethane sulfonate

Guidance literature:: Multi-step reaction with 9 steps

1.1: Lawessons reagent; pyridine / 18 h / 100 °C

2.1: 1 h / 95 °C

3.1: acetic acid / 13 h / 105 °C

4.1: N-Bromosuccinimide / tetrahydrofuran / 2 h / 0 - 20 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / ethanol; water; toluene / 15 h / Reflux

6.1: N-chloro-succinimide / chloroform / 22 h / Reflux

7.1: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); sodium carbonate / water; N,N-dimethyl-formamide / 1 h / 160 °C / Microwave irradiation

8.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 49 h / 50 °C

9.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

9.2: 2.5 h / 0 - 20 °C

With Lawessons reagent; pyridine; N-chloro-succinimide; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); hydrogen; sodium hydride; sodium hydrogencarbonate; sodium carbonate; acetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; chloroform; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1204296-84-3
5,11-dihydro-6H-pyrido[2,3-b][1,4]benzo diazepine-6-thione

: 1374263-66-7
4-[3-(4-{1-[(tert-butoxycarbonyl)amino]cyclobutyl}phenyl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-2-yl]phenyl trifluoromethane sulfonate

Guidance literature:: Multi-step reaction with 8 steps

1.1: 1 h / 95 °C

2.1: acetic acid / 13 h / 105 °C

3.1: N-Bromosuccinimide / tetrahydrofuran / 2 h / 0 - 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / ethanol; water; toluene / 15 h / Reflux

5.1: N-chloro-succinimide / chloroform / 22 h / Reflux

6.1: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); sodium carbonate / water; N,N-dimethyl-formamide / 1 h / 160 °C / Microwave irradiation

7.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 49 h / 50 °C

8.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

8.2: 2.5 h / 0 - 20 °C

With N-chloro-succinimide; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); hydrogen; sodium hydride; sodium hydrogencarbonate; sodium carbonate; acetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; chloroform; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1374260-82-8
9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzo diazepine

: 1374263-66-7
4-[3-(4-{1-[(tert-butoxycarbonyl)amino]cyclobutyl}phenyl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-2-yl]phenyl trifluoromethane sulfonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide / tetrahydrofuran / 2 h / 0 - 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / ethanol; water; toluene / 15 h / Reflux

3.1: N-chloro-succinimide / chloroform / 22 h / Reflux

4.1: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); sodium carbonate / water; N,N-dimethyl-formamide / 1 h / 160 °C / Microwave irradiation

5.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 49 h / 50 °C

6.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

6.2: 2.5 h / 0 - 20 °C

With N-chloro-succinimide; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); hydrogen; sodium hydride; sodium hydrogencarbonate; sodium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; chloroform; water; N,N-dimethyl-formamide; toluene;