Technology Process of 8a-Methyl-2-(p-toluenesulfonyl)-cis-1,2,3,4,4a,5,6,8a-octahydro-1,6-dioxoisoquinoline
There total 5 articles about 8a-Methyl-2-(p-toluenesulfonyl)-cis-1,2,3,4,4a,5,6,8a-octahydro-1,6-dioxoisoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1) KN(TMS)2 / 1) THF, toluene, -60 deg C, 15 min, 2) -60 deg C to r.t.
2: m-CPBA / CH2Cl2 / 1 h / Ambient temperature
3: toluene / 1 h / Heating
4: 2) camphorsulfonic acid / 1) p-cymene, reflux, 5 h, 2) THF, 0 deg C, 1 h
With
camphor-10-sulfonic acid; potassium hexamethylsilazane; 3-chloro-benzenecarboperoxoic acid;
In
dichloromethane; toluene;
DOI:10.1021/jo00047a031
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 70 percent / KN(TMS)2 / tetrahydrofuran; toluene / 0.5 h / -60 °C
2: 1) KN(TMS)2 / 1) THF, toluene, -60 deg C, 15 min, 2) -60 deg C to r.t.
3: m-CPBA / CH2Cl2 / 1 h / Ambient temperature
4: toluene / 1 h / Heating
5: 2) camphorsulfonic acid / 1) p-cymene, reflux, 5 h, 2) THF, 0 deg C, 1 h
With
camphor-10-sulfonic acid; potassium hexamethylsilazane; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jo00047a031
- Guidance literature:
-
Multi-step reaction with 3 steps
1: m-CPBA / CH2Cl2 / 1 h / Ambient temperature
2: toluene / 1 h / Heating
3: 2) camphorsulfonic acid / 1) p-cymene, reflux, 5 h, 2) THF, 0 deg C, 1 h
With
camphor-10-sulfonic acid; 3-chloro-benzenecarboperoxoic acid;
In
dichloromethane; toluene;
DOI:10.1021/jo00047a031
