3-O-descladinosyl-3-O-[3-[4-(1-imidazoly)phenyl]-(E)-prop-2-enyl]-6-O-methylerythromycin A 9-(E)-O-(2-chlorobenzyl)oxime 11,12-cyclic carbonate

Base Information

Chemical Name:3-O-descladinosyl-3-O-[3-[4-(1-imidazoly)phenyl]-(E)-prop-2-enyl]-6-O-methylerythromycin A 9-(E)-O-(2-chlorobenzyl)oxime 11,12-cyclic carbonate
CAS No.:1360059-57-9
Molecular Formula:C₅₀H₆₉ClN₄O₁₁
Molecular Weight:937.571
Hs Code.:

3-O-descladinosyl-3-O-[3-[4-(1-imidazoly)phenyl]-(E)-prop-2-enyl]-6-O-methylerythromycin A 9-(E)-O-(2-chlorobenzyl)oxime 11,12-cyclic carbonate

Synonyms:

Suppliers and Price of 3-O-descladinosyl-3-O-[3-[4-(1-imidazoly)phenyl]-(E)-prop-2-enyl]-6-O-methylerythromycin A 9-(E)-O-(2-chlorobenzyl)oxime 11,12-cyclic carbonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-O-descladinosyl-3-O-[3-[4-(1-imidazoly)phenyl]-(E)-prop-2-enyl]-6-O-methylerythromycin A 9-(E)-O-(2-chlorobenzyl)oxime 11,12-cyclic carbonate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-O-descladinosyl-3-O-[3-[4-(1-imidazoly)phenyl]-(E)-prop-2-enyl]-6-O-methylerythromycin A 9-(E)-O-(2-chlorobenzyl)oxime 11,12-cyclic carbonate

There total 2 articles about 3-O-descladinosyl-3-O-[3-[4-(1-imidazoly)phenyl]-(E)-prop-2-enyl]-6-O-methylerythromycin A 9-(E)-O-(2-chlorobenzyl)oxime 11,12-cyclic carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.6%

: 2'-O-Ac-3-O-allyl-6-O-methylerythromycin A 9-O-(2-chlorobenzyl)oxime 11,12-carbonate

: 10040-96-7
1-(4-bromophenyl)-1H-imidazole

: 1360059-57-9
3-O-descladinosyl-3-O-[3-[4-(1-imidazoly)phenyl]-(E)-prop-2-enyl]-6-O-methylerythromycin A 9-(E)-O-(2-chlorobenzyl)oxime 11,12-cyclic carbonate

Guidance literature:: 2'-O-Ac-3-O-allyl-6-O-methylerythromycin A 9-O-(2-chlorobenzyl)oxime 11,12-carbonate; 1-(4-bromophenyl)-1H-imidazole; With trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); tetrabutylammomium bromide; sodium acetate; In N,N-dimethyl-formamide; at 100 ℃; for 72h;

With methanol; at 65 ℃; for 3h;
DOI:10.1016/j.ejmech.2012.01.023

Reference yield:

: 152235-30-8
C₃₇H₆₁ClN₂O₁₀

: 1360059-57-9
3-O-descladinosyl-3-O-[3-[4-(1-imidazoly)phenyl]-(E)-prop-2-enyl]-6-O-methylerythromycin A 9-(E)-O-(2-chlorobenzyl)oxime 11,12-cyclic carbonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane / 1 h / 25 °C

1.2: 20 h / -5 - 20 °C

1.3: 0.5 h / 25 °C

2.1: trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); tetrabutylammomium bromide; sodium acetate / N,N-dimethyl-formamide / 72 h / 100 °C

2.2: 3 h / 65 °C

With trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); tetrabutylammomium bromide; sodium acetate; In dichloromethane; N,N-dimethyl-formamide; 2.1: Heck reaction;
DOI:10.1016/j.ejmech.2012.01.023