C₂₁H₂₆N₂O₃

Base Information

• Chemical Name: C₂₁H₂₆N₂O₃
• CAS No.: 1357190-96-5
• Molecular Formula: C₂₁H₂₆N₂O₃
• Molecular Weight: 354.449
• Mol file: 1357190-96-5.mol

Synonyms:

Chemical Property of C₂₁H₂₆N₂O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₂₆N₂O₃

There total 5 articles about C₂₁H₂₆N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C16H19IO (1357190-97-6) + (R)-(+)-N-hydroxy-N-(3-butyn-2-yl)urea (154355-92-7) → C21H26N2O3 (1357190-96-5)

Guidance literature:

With dichloro bis(acetonitrile) palladium(II); copper(l) iodide; diisopropylamine; triphenylphosphine; In ethyl acetate; at 20 ℃; for 2.05h; optical yield given as %ee; enantioselective reaction;

DOI:10.1002/anie.201106010

Reference yield:

C16H19IO (1357190-97-6) + (S)-(1-methyl-2-propynyl)-N-hydroxyurea → C21H26N2O3 (1357190-95-4) + C21H26N2O3 (1357190-96-5)

Guidance literature:

With dichloro bis(acetonitrile) palladium(II); copper(l) iodide; diisopropylamine; triphenylphosphine; In ethyl acetate; at 20 ℃; for 2.05h; optical yield given as %ee; enantioselective reaction;

DOI:10.1002/anie.201106010

Reference yield:

1-Adamantyl bromide (768-90-1) → C21H26N2O3 (1357190-96-5)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / ethyl acetate / 6 h / 140 °C / Microwave irradiation

2: copper(l) iodide; dichloro bis(acetonitrile) palladium(II); diisopropylamine; triphenylphosphine / ethyl acetate / 2.05 h / 20 °C

With pyridine; dichloro bis(acetonitrile) palladium(II); copper(l) iodide; diisopropylamine; triphenylphosphine; In ethyl acetate; 2: Sonogashira coupling;

DOI:10.1002/anie.201106010

upstream raw materials:

1-Adamantyl bromide

C₁₆H₁₉IO

(R)-(+)-N-hydroxy-N-(3-butyn-2-yl)urea

3-Iodophenol

Refernces