Technology Process of (tert-butyl)((S,3Z,5E)-4-ethyl-6-((2R,6R)-6-isopropoxy-3,6-dihydro-2H-pyran-2-yl)-2-methylhexa-3,5-dienyloxy)(diphenyl)silane
There total 16 articles about (tert-butyl)((S,3Z,5E)-4-ethyl-6-((2R,6R)-6-isopropoxy-3,6-dihydro-2H-pyran-2-yl)-2-methylhexa-3,5-dienyloxy)(diphenyl)silane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: DIBAL-H / CH2Cl2 / 0.75 h / -23 °C
2: Dowex 50wX8-200 resin / methanol / 12 h / 20 °C
3: 0.011 g / MnO2 / CH2Cl2 / 1 h / 20 °C
4: 91 percent / 2,6-lutidine / CH2Cl2 / 0.5 h / 20 °C
5: DIBAL-H / CH2Cl2 / -23 - 20 °C
6: 0.121 g / PPTS / 1 h / 20 °C
7: 99 percent / TBAF / tetrahydrofuran / 15 h / 20 °C
8: (COCl)2; DMSO; Et3N / CH2Cl2 / -78 - 20 °C
9: n-BuLi; DMSO / 1 h / -78 °C
With
2,6-dimethylpyridine; manganese(IV) oxide; n-butyllithium; oxalyl dichloride; Dowex 50wx8-200 resin; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane;
8: Swern oxidation;
DOI:10.1021/jo050352u
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: NaH / tetrahydrofuran / 0.25 h / 0 °C
1.2: tetrahydrofuran / 2 h / 0 °C
2.1: 90 percent / DIBAL-H / CH2Cl2 / 1 h / -23 °C
3.1: 95 percent / triphenylphosphine; CBr4 / acetonitrile / 1 h / 20 °C
4.1: acetonitrile / 0.5 h / 20 °C
5.1: n-BuLi; DMSO / 1 h / -78 °C
With
n-butyllithium; carbon tetrabromide; sodium hydride; diisobutylaluminium hydride; dimethyl sulfoxide; triphenylphosphine;
In
tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jo050352u
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 90 percent / (COCl)2; DMSO; triethylamine / CH2Cl2 / -78 - 20 °C
2.1: NaH / tetrahydrofuran / 0.25 h / 0 °C
2.2: tetrahydrofuran / 2 h / 0 °C
3.1: 90 percent / DIBAL-H / CH2Cl2 / 1 h / -23 °C
4.1: 95 percent / triphenylphosphine; CBr4 / acetonitrile / 1 h / 20 °C
5.1: acetonitrile / 0.5 h / 20 °C
6.1: n-BuLi; DMSO / 1 h / -78 °C
With
n-butyllithium; oxalyl dichloride; carbon tetrabromide; sodium hydride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; triphenylphosphine;
In
tetrahydrofuran; dichloromethane; acetonitrile;
1.1: Swern oxidation;
DOI:10.1021/jo050352u
