C₃₂H₃₁F₃N₆O

Base Information

• Chemical Name: C₃₂H₃₁F₃N₆O
• CAS No.: 1421685-07-5
• Molecular Formula: C₃₂H₃₁F₃N₆O
• Molecular Weight: 572.633
• Mol file: 1421685-07-5.mol

Synonyms:

Chemical Property of C₃₂H₃₁F₃N₆O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₂H₃₁F₃N₆O

There total 9 articles about C₃₂H₃₁F₃N₆O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-iodo-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl) phenyl)benzamide (943320-50-1) → C32H31F3N6O (1421685-07-5)

Guidance literature:

Multi-step reaction with 4 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / acetonitrile / 20 - 60 °C / Inert atmosphere

2: potassium carbonate; methanol / 20 °C / Inert atmosphere

3: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 - 80 °C / Sealed tube; Inert atmosphere

4: tetrabutyl ammonium fluoride / tetrahydrofuran / Reflux

With methanol; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; 1: |Sonogashira Cross-Coupling / 3: |Sonogashira Cross-Coupling;

DOI:10.1021/jm301581y

Reference yield:

methyl 3-iodo-4-methylbenzoate (90347-66-3) → C32H31F3N6O (1421685-07-5)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium tert-butylate / tetrahydrofuran / 3 h / -20 - 20 °C / Inert atmosphere

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / acetonitrile / 20 - 60 °C / Inert atmosphere

3: potassium carbonate; methanol / 20 °C / Inert atmosphere

4: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 - 80 °C / Sealed tube; Inert atmosphere

5: tetrabutyl ammonium fluoride / tetrahydrofuran / Reflux

With methanol; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium tert-butylate; tetrabutyl ammonium fluoride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; 2: |Sonogashira Cross-Coupling / 4: |Sonogashira Cross-Coupling;

DOI:10.1021/jm301581y

Reference yield:

4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethylaniline (694499-26-8) → C32H31F3N6O (1421685-07-5)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium tert-butylate / tetrahydrofuran / 3 h / -20 - 20 °C / Inert atmosphere

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / acetonitrile / 20 - 60 °C / Inert atmosphere

3: potassium carbonate; methanol / 20 °C / Inert atmosphere

4: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 - 80 °C / Sealed tube; Inert atmosphere

5: tetrabutyl ammonium fluoride / tetrahydrofuran / Reflux

With methanol; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium tert-butylate; tetrabutyl ammonium fluoride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; 2: |Sonogashira Cross-Coupling / 4: |Sonogashira Cross-Coupling;

DOI:10.1021/jm301581y

upstream raw materials:

3-iodo-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl) phenyl)benzamide

3-ethynyl-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

5-Bromo-3-cyclopropyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazolo[3,4-b]pyridine

methyl 3-iodo-4-methylbenzoate