Technology Process of 1-ethyl-6-methoxy-1,2,3,4-tetrahydroisoquinolin-7-ol
There total 6 articles about 1-ethyl-6-methoxy-1,2,3,4-tetrahydroisoquinolin-7-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N-[2-(4-benzyloxy-3-methoxyphenyl)ethyl]propionamide;
With
trichlorophosphate;
In
acetonitrile;
Reflux;
With
methanol; sodium tetrahydroborate;
at 0 - 20 ℃;
With
hydrogenchloride; hydrogen;
palladium 10% on activated carbon;
In
methanol; water;
at 20 ℃;
for 12h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydrogenchloride / diethyl ether
2.1: triethylamine / dichloromethane / 0.5 - 1 h / 0 °C
3.1: trichlorophosphate / acetonitrile / 2 - 5 h / Heating / reflux
3.2: 24 h / 0 - 20 °C
3.3: 12 h / 20 °C
With
hydrogenchloride; triethylamine; trichlorophosphate;
In
diethyl ether; dichloromethane; acetonitrile;
3.1: Bischler-Napieralski Reaction;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: triethylamine / chloroform / 24 h / 20 °C
2.1: potassium carbonate / acetone / 12 h / Heating / reflux
3.1: trifluoroacetic acid / dichloromethane / 0.67 h / 0 °C
4.1: hydrogenchloride / diethyl ether
5.1: triethylamine / dichloromethane / 0.5 - 1 h / 0 °C
6.1: trichlorophosphate / acetonitrile / 2 - 5 h / Heating / reflux
6.2: 24 h / 0 - 20 °C
6.3: 12 h / 20 °C
With
hydrogenchloride; potassium carbonate; triethylamine; trifluoroacetic acid; trichlorophosphate;
In
diethyl ether; dichloromethane; chloroform; acetone; acetonitrile;
6.1: Bischler-Napieralski Reaction;
