(R)-2-[(2R,4S,5S,6R)-6-{(1R,3R,4S,5S)-1-Hydroxy-5-[(4R,5R)-5-((R)-1-hydroxy-propyl)-2,2,5-trimethyl-[1,3]dioxolan-4-yl]-4-methoxymethoxy-1,3-dimethyl-hexyl}-5-methyl-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxan-4-yl]-thiopropionic acid S-pyridin-2-yl ester

Base Information

Chemical Name:(R)-2-[(2R,4S,5S,6R)-6-{(1R,3R,4S,5S)-1-Hydroxy-5-[(4R,5R)-5-((R)-1-hydroxy-propyl)-2,2,5-trimethyl-[1,3]dioxolan-4-yl]-4-methoxymethoxy-1,3-dimethyl-hexyl}-5-methyl-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxan-4-yl]-thiopropionic acid S-pyridin-2-yl ester
CAS No.:78442-88-3
Molecular Formula:C₄₁H₆₃NO₉S
Molecular Weight:746.019
Hs Code.:

(R)-2-[(2R,4S,5S,6R)-6-{(1R,3R,4S,5S)-1-Hydroxy-5-[(4R,5R)-5-((R)-1-hydroxy-propyl)-2,2,5-trimethyl-[1,3]dioxolan-4-yl]-4-methoxymethoxy-1,3-dimethyl-hexyl}-5-methyl-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxan-4-yl]-thiopropionic acid S-pyridin-2-yl ester

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Chemical Property of (R)-2-[(2R,4S,5S,6R)-6-{(1R,3R,4S,5S)-1-Hydroxy-5-[(4R,5R)-5-((R)-1-hydroxy-propyl)-2,2,5-trimethyl-[1,3]dioxolan-4-yl]-4-methoxymethoxy-1,3-dimethyl-hexyl}-5-methyl-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxan-4-yl]-thiopropionic acid S-pyridin-2-yl ester

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Technology Process of (R)-2-[(2R,4S,5S,6R)-6-{(1R,3R,4S,5S)-1-Hydroxy-5-[(4R,5R)-5-((R)-1-hydroxy-propyl)-2,2,5-trimethyl-[1,3]dioxolan-4-yl]-4-methoxymethoxy-1,3-dimethyl-hexyl}-5-methyl-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxan-4-yl]-thiopropionic acid S-pyridin-2-yl ester

There total 2 articles about (R)-2-[(2R,4S,5S,6R)-6-{(1R,3R,4S,5S)-1-Hydroxy-5-[(4R,5R)-5-((R)-1-hydroxy-propyl)-2,2,5-trimethyl-[1,3]dioxolan-4-yl]-4-methoxymethoxy-1,3-dimethyl-hexyl}-5-methyl-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxan-4-yl]-thiopropionic acid S-pyridin-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 73371-99-0
2-thiopyridyl chloroformate

: 78443-05-7,78512-94-4
(1S,2R,5R,6R,10R,11S,12R,13R,15R,16R,18R,20S)-5-Ethyl-15-hydroxy-12-methoxymethoxy-2,6,8,8,11,13,15,20-octamethyl-18-(2,4,6-trimethyl-phenyl)-4,7,9,17,19-pentaoxa-tricyclo[14.3.1.0^6,10]icosan-3-one

: 78442-88-3,78512-10-4
(R)-2-[(2R,4S,5S,6R)-6-{(1R,3R,4R,5S)-1-Hydroxy-5-[(4R,5R)-5-((R)-1-hydroxy-propyl)-2,2,5-trimethyl-[1,3]dioxolan-4-yl]-4-methoxymethoxy-1,3-dimethyl-hexyl}-5-methyl-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxan-4-yl]-thiopropionic acid S-pyridin-2-yl ester

Guidance literature:: With sodium hydroxide; triethylamine; Multistep reaction; 1.) EtOH, t-BuOH, room temperature, 2.) CH₂Cl₂, 0 deg C;
DOI:10.1021/ja00401a050

Reference yield:

: 73371-99-0
2-thiopyridyl chloroformate

: 78443-05-7,78512-94-4
(1S,2R,5R,6R,10R,11S,12S,13R,15R,16R,18R,20S)-5-Ethyl-15-hydroxy-12-methoxymethoxy-2,6,8,8,11,13,15,20-octamethyl-18-(2,4,6-trimethyl-phenyl)-4,7,9,17,19-pentaoxa-tricyclo[14.3.1.0^6,10]icosan-3-one

: 78442-88-3,78512-10-4
(R)-2-[(2R,4S,5S,6R)-6-{(1R,3R,4S,5S)-1-Hydroxy-5-[(4R,5R)-5-((R)-1-hydroxy-propyl)-2,2,5-trimethyl-[1,3]dioxolan-4-yl]-4-methoxymethoxy-1,3-dimethyl-hexyl}-5-methyl-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxan-4-yl]-thiopropionic acid S-pyridin-2-yl ester

Guidance literature:: With sodium hydroxide; triethylamine; Multistep reaction; 1.) EtOH, t-BuOH, room temperature, 2.) CH₂Cl₂, 0 deg C;
DOI:10.1021/ja00401a050