C₃₆H₅₇N₅O₇

Base Information

• Chemical Name: C₃₆H₅₇N₅O₇
• CAS No.: 1412911-49-9
• Molecular Formula: C₃₆H₅₇N₅O₇
• Molecular Weight: 671.878
• Mol file: 1412911-49-9.mol

Synonyms:

Chemical Property of C₃₆H₅₇N₅O₇

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₆H₅₇N₅O₇

There total 23 articles about C₃₆H₅₇N₅O₇ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C36H59N5O8 (1412893-36-7) → C36H57N5O7 (1412911-49-9)

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.tetlet.2012.09.018

Reference yield:

C32H45NO5 → C36H57N5O7 (1412911-49-9)

Guidance literature:

Multi-step reaction with 6 steps

1: trifluoroacetic acid / dichloromethane / 0 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

3: 10% Pd/C; hydrogen / methanol

4: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / water; acetonitrile / 2 h / 0 - 20 °C

5: trifluoroacetic acid / dichloromethane / 0 °C

6: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 0 - 20 °C

With 1-hydroxy-7-aza-benzotriazole; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; 10% Pd/C; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In methanol; dichloromethane; water; acetonitrile;

DOI:10.1016/j.tetlet.2012.09.018

Reference yield:

C18H28O2 → C36H57N5O7 (1412911-49-9)

Guidance literature:

Multi-step reaction with 7 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 °C

2: trifluoroacetic acid / dichloromethane / 0 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

4: 10% Pd/C; hydrogen / methanol

5: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / water; acetonitrile / 2 h / 0 - 20 °C

6: trifluoroacetic acid / dichloromethane / 0 °C

7: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 0 - 20 °C

With 1-hydroxy-7-aza-benzotriazole; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; di-isopropyl azodicarboxylate; 10% Pd/C; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile; 1: |Mitsunobu Displacement;

DOI:10.1016/j.tetlet.2012.09.018

upstream raw materials:

(S)-4-benzyl-3-((2S,3R)-5-benzyloxy-3-hydroxy-2-methylpentanoyl)-2-oxazolidinone

(2R,3R)-5-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-pentan-1-ol

N-tert-butoxycarbonyl-L-leucine

(2S)-2-[[2-(tert-butoxycarbonylamino)acetyl]amino]-3-methylbutanoic acid