ethyl (E)-10-<(benzyloxycarbonyl)amino>-4--2-(formylamino)dec-3-enoate

Base Information

Chemical Name:ethyl (E)-10-<(benzyloxycarbonyl)amino>-4--2-(formylamino)dec-3-enoate
CAS No.:152564-55-1
Molecular Formula:C₂₈H₄₅N₂O₈P
Molecular Weight:568.648
Hs Code.:

ethyl (E)-10-<(benzyloxycarbonyl)amino>-4-<diisopropylphosphonomethyl>-2-(formylamino)dec-3-enoate

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Chemical Property of ethyl (E)-10-<(benzyloxycarbonyl)amino>-4--2-(formylamino)dec-3-enoate

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Technology Process of ethyl (E)-10-<(benzyloxycarbonyl)amino>-4--2-(formylamino)dec-3-enoate

There total 8 articles about ethyl (E)-10-<(benzyloxycarbonyl)amino>-4--2-(formylamino)dec-3-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 19008-71-0
8-aminooctan-1-ol

: 152564-55-1
ethyl (E)-10-<(benzyloxycarbonyl)amino>-4--2-(formylamino)dec-3-enoate

Guidance literature:: Multi-step reaction with 7 steps

1: 89 percent / NaHCO₃ / acetone; H₂O / 21 h / Ambient temperature

2: 1.) oxalyl chloride, DMSO, 2.) N-ethyldiisopropylamine / 1.) CH₂Cl₂, -60 to -50 deg C, 30 min, 2.) CH₂Cl₂, -50 deg C, 1 h

3: piperazine, AcOH / H₂O / 1 h / Heating

4: 33 percent / Cu₂O / toluene / 3 h / 40 °C

5: 100 percent / H₂O / tetrahydrofuran / 4 h / Heating

6: 1,5-hexadiene, SOBr₂ / 1,2-dichloro-ethane / a) 10 deg C, 1 h, b) RT, 1.5 h

7: 17 h / 80 °C / 75.01 Torr

With piperazine; copper(I) oxide; sulfurous dibromide; oxalyl dichloride; 1,5-Hexadien; water; sodium hydrogencarbonate; acetic acid; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; 1,2-dichloro-ethane; acetone; toluene;
DOI:10.1021/jm00075a029

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 152564-55-1
ethyl (E)-10-<(benzyloxycarbonyl)amino>-4--2-(formylamino)dec-3-enoate

Guidance literature:: Multi-step reaction with 7 steps

1: 89 percent / NaHCO₃ / acetone; H₂O / 21 h / Ambient temperature

2: 1.) oxalyl chloride, DMSO, 2.) N-ethyldiisopropylamine / 1.) CH₂Cl₂, -60 to -50 deg C, 30 min, 2.) CH₂Cl₂, -50 deg C, 1 h

3: piperazine, AcOH / H₂O / 1 h / Heating

4: 33 percent / Cu₂O / toluene / 3 h / 40 °C

5: 100 percent / H₂O / tetrahydrofuran / 4 h / Heating

6: 1,5-hexadiene, SOBr₂ / 1,2-dichloro-ethane / a) 10 deg C, 1 h, b) RT, 1.5 h

7: 17 h / 80 °C / 75.01 Torr

With piperazine; copper(I) oxide; sulfurous dibromide; oxalyl dichloride; 1,5-Hexadien; water; sodium hydrogencarbonate; acetic acid; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; 1,2-dichloro-ethane; acetone; toluene;
DOI:10.1021/jm00075a029

Reference yield:

: 134477-39-7
8-<(benzyloxycarbonyl)amino>octan-1-ol

: 152564-55-1
ethyl (E)-10-<(benzyloxycarbonyl)amino>-4--2-(formylamino)dec-3-enoate

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) oxalyl chloride, DMSO, 2.) N-ethyldiisopropylamine / 1.) CH₂Cl₂, -60 to -50 deg C, 30 min, 2.) CH₂Cl₂, -50 deg C, 1 h

2: piperazine, AcOH / H₂O / 1 h / Heating

3: 33 percent / Cu₂O / toluene / 3 h / 40 °C

4: 100 percent / H₂O / tetrahydrofuran / 4 h / Heating

5: 1,5-hexadiene, SOBr₂ / 1,2-dichloro-ethane / a) 10 deg C, 1 h, b) RT, 1.5 h

6: 17 h / 80 °C / 75.01 Torr

With piperazine; copper(I) oxide; sulfurous dibromide; oxalyl dichloride; 1,5-Hexadien; water; acetic acid; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; 1,2-dichloro-ethane; toluene;
DOI:10.1021/jm00075a029