Methyl 4-[[(2-chlorophenyl)methylene]amino]-1H-indole-6-carboxylate

Base Information

Chemical Name:Methyl 4-[[(2-chlorophenyl)methylene]amino]-1H-indole-6-carboxylate
CAS No.:121561-16-8
Molecular Formula:C₁₇H₁₃ClN₂O₂
Molecular Weight:312.755
Hs Code.:
DSSTox Substance ID:DTXSID001163118

Synonyms:DTXSID001163118;Methyl 4-[[(2-chlorophenyl)methylene]amino]-1H-indole-6-carboxylate;121561-16-8

Suppliers and Price of Methyl 4-[[(2-chlorophenyl)methylene]amino]-1H-indole-6-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl 4-[[(2-chlorophenyl)methylene]amino]-1H-indole-6-carboxylate

Chemical Property:

XLogP3:3.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:312.0665554
Heavy Atom Count:22
Complexity:429

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)C1=CC2=C(C=CN2)C(=C1)N=CC3=CC=CC=C3Cl

Technology Process of Methyl 4-[[(2-chlorophenyl)methylene]amino]-1H-indole-6-carboxylate

There total 2 articles about Methyl 4-[[(2-chlorophenyl)methylene]amino]-1H-indole-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 89-98-5
2-chloro-benzaldehyde

: 121561-15-7
methyl 4-amino-1H-indole-6-carboxylate

: 121561-16-8
4-(2-chlorobenzylideneamino)-6-methoxycarbonylindole

Guidance literature:: In benzene; Heating; azeotropic removal of water;

Reference yield:

: 49592-71-4
methyl 4-methyl-3,5-dinitrobenzoate

: 121561-16-8
4-(2-chlorobenzylideneamino)-6-methoxycarbonylindole

Guidance literature:: Multi-step reaction with 2 steps

1: 2) H₂ / 2) Raney Ni / 1) DMF, reflux, 10 min, 2) THF-CH₃OH, atm. pressure, 2.5 h

2: 79 percent / benzene / Heating; azeotropic removal of water

With hydrogen; nickel; In benzene;