Technology Process of 1-Ethyl-5-methoxy-1,2,3,3a,8,8a-hexahydro-indeno[2,1-b]pyrrole
There total 5 articles about 1-Ethyl-5-methoxy-1,2,3,3a,8,8a-hexahydro-indeno[2,1-b]pyrrole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 96 percent / H2, HCl(gas) / 10percent Pd/C / acetic acid / 4 h / 70 °C / 2585.7 Torr
2: 96 percent / LiAlH4 / tetrahydrofuran / 5 h / Heating
3: pyridine / CH2Cl2 / 1 h / Ambient temperature
4: 1.) BH3-Me2S, 2.) concd. HCl / 1.) THF, reflux, 3 h, 2.) THF, methanol, RT, overnight
With
pyridine; hydrogenchloride; lithium aluminium tetrahydride; dimethylsulfide borane complex; hydrogen;
palladium on activated charcoal;
In
tetrahydrofuran; dichloromethane; acetic acid;
DOI:10.1021/jm00086a011
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 72 percent / H2, HCl(gas) / 10percent Pd/C / acetic acid / 4 h / 2585.7 Torr / Heating
2: 96 percent / H2, HCl(gas) / 10percent Pd/C / acetic acid / 4 h / 70 °C / 2585.7 Torr
3: 96 percent / LiAlH4 / tetrahydrofuran / 5 h / Heating
4: pyridine / CH2Cl2 / 1 h / Ambient temperature
5: 1.) BH3-Me2S, 2.) concd. HCl / 1.) THF, reflux, 3 h, 2.) THF, methanol, RT, overnight
With
pyridine; hydrogenchloride; lithium aluminium tetrahydride; dimethylsulfide borane complex; hydrogen;
palladium on activated charcoal;
In
tetrahydrofuran; dichloromethane; acetic acid;
DOI:10.1021/jm00086a011
- Guidance literature:
-
Multi-step reaction with 2 steps
1: pyridine / CH2Cl2 / 1 h / Ambient temperature
2: 1.) BH3-Me2S, 2.) concd. HCl / 1.) THF, reflux, 3 h, 2.) THF, methanol, RT, overnight
With
pyridine; hydrogenchloride; dimethylsulfide borane complex;
In
dichloromethane;
DOI:10.1021/jm00086a011
