Phosphonic acid, [[4-[2-[[5-[(2,5-dioxo-1-pyrrolidinyl)oxy]-1,5-dioxopentyl]amino]ethyl]phen yl]methyl]-, mono(1-methylcyclohexyl) ester

Base Information

• Chemical Name: Phosphonic acid, [[4-[2-[[5-[(2,5-dioxo-1-pyrrolidinyl)oxy]-1,5-dioxopentyl]amino]ethyl]phen yl]methyl]-, mono(1-methylcyclohexyl) ester
• CAS No.: 137668-71-4
• Molecular Formula: C25H35N2O8P
• Molecular Weight: 522.535
• Mol file: 137668-71-4.mol

Synonyms:

Chemical Property of Phosphonic acid, [[4-[2-[[5-[(2,5-dioxo-1-pyrrolidinyl)oxy]-1,5-dioxopentyl]amino]ethyl]phen yl]methyl]-, mono(1-methylcyclohexyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phosphonic acid, [[4-[2-[[5-[(2,5-dioxo-1-pyrrolidinyl)oxy]-1,5-dioxopentyl]amino]ethyl]phen yl]methyl]-, mono(1-methylcyclohexyl) ester

There total 7 articles about Phosphonic acid, [[4-[2-[[5-[(2,5-dioxo-1-pyrrolidinyl)oxy]-1,5-dioxopentyl]amino]ethyl]phen yl]methyl]-, mono(1-methylcyclohexyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-Methylcyclohexanol (590-67-0) → 4-(2-{4-[Hydroxy-(1-methyl-cyclohexyloxy)-phosphorylmethyl]-phenyl}-ethylcarbamoyl)-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester (137668-71-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) phosphorus trichloride, pyridine / 1.) benzene, RT, 8 h, 2.) overnight

2: NaH / tetrahydrofuran

3: H₂ / Pd(OH)2-C / methanol

With pyridine; hydrogen; sodium hydride; phosphorus trichloride; palladium hydroxide - carbon; In tetrahydrofuran; methanol;

DOI:10.1021/ja00022a054

Reference yield:

4-(2-aminoethyl)-benzyl alcohol (64353-30-6) → 4-(2-{4-[Hydroxy-(1-methyl-cyclohexyloxy)-phosphorylmethyl]-phenyl}-ethylcarbamoyl)-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester (137668-71-4)

Guidance literature:

Multi-step reaction with 5 steps

1: NaHCO₃ / H₂O

2: Br₂, PPh₃ / acetonitrile

3: NaH / tetrahydrofuran

4: H₂ / Pd(OH)2-C / methanol

With hydrogen; bromine; sodium hydride; sodium hydrogencarbonate; triphenylphosphine; palladium hydroxide - carbon; In tetrahydrofuran; methanol; water; acetonitrile;

DOI:10.1021/ja00022a054

Reference yield:

1-methylcyclohexyl benzyl phosphite → 4-(2-{4-[Hydroxy-(1-methyl-cyclohexyloxy)-phosphorylmethyl]-phenyl}-ethylcarbamoyl)-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester (137668-71-4)

Guidance literature:

Multi-step reaction with 3 steps

1: NaH / tetrahydrofuran

2: H₂ / Pd(OH)2-C / methanol

With hydrogen; sodium hydride; palladium hydroxide - carbon; In tetrahydrofuran; methanol;

DOI:10.1021/ja00022a054

upstream raw materials:

5-[(2',5'-dioxo-1'-pyrrolidinyl)oxy]-5-oxopentanoyl chloride

[4-(2-Amino-ethyl)-benzyl]-phosphonic acid mono-(1-methyl-cyclohexyl) ester

1-Methylcyclohexanol

4-(2-aminoethyl)-benzyl alcohol