6-bromo-3-[dimethyl(thexyl)silyloxy]-2-[(R)-2-[2-(2-hydroxyacetylamino)acetylamino]-2-(3-methyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-5-methoxybenzoic acid

Base Information

Chemical Name:6-bromo-3-[dimethyl(thexyl)silyloxy]-2-[(R)-2-[2-(2-hydroxyacetylamino)acetylamino]-2-(3-methyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-5-methoxybenzoic acid
CAS No.:1275617-46-3
Molecular Formula:C₂₆H₃₉BrN₄O₈SSi
Molecular Weight:675.673
Hs Code.:

6-bromo-3-[dimethyl(thexyl)silyloxy]-2-[(R)-2-[2-(2-hydroxyacetylamino)acetylamino]-2-(3-methyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-5-methoxybenzoic acid

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Chemical Property of 6-bromo-3-[dimethyl(thexyl)silyloxy]-2-[(R)-2-[2-(2-hydroxyacetylamino)acetylamino]-2-(3-methyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-5-methoxybenzoic acid

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Technology Process of 6-bromo-3-[dimethyl(thexyl)silyloxy]-2-[(R)-2-[2-(2-hydroxyacetylamino)acetylamino]-2-(3-methyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-5-methoxybenzoic acid

There total 11 articles about 6-bromo-3-[dimethyl(thexyl)silyloxy]-2-[(R)-2-[2-(2-hydroxyacetylamino)acetylamino]-2-(3-methyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-5-methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₄₃BrN₄O₈SSi

: 1275617-46-3
6-bromo-3-[dimethyl(thexyl)silyloxy]-2-[(R)-2-[2-(2-hydroxyacetylamino)acetylamino]-2-(3-methyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-5-methoxybenzoic acid

Guidance literature:: With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 0 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm1014023

Reference yield:

: 1275617-08-7
allyl 2-[(R)-2-amino-2-(3-methyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-6-bromo-3-[dimethyl(thexyl)silyloxy]-5-methoxybenzoate

: 1275617-46-3
6-bromo-3-[dimethyl(thexyl)silyloxy]-2-[(R)-2-[2-(2-hydroxyacetylamino)acetylamino]-2-(3-methyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-5-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1,2-dichloro-ethane / acetonitrile / 5 h / 0 °C / Inert atmosphere

2: toluene-4-sulfonic acid / methanol / 2 h / 20 °C / Inert atmosphere

3: morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; toluene-4-sulfonic acid; 1,2-dichloro-ethane; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1021/jm1014023

Reference yield:

: C₄₈H₅₇BrN₄O₈SSi

: 1275617-46-3
6-bromo-3-[dimethyl(thexyl)silyloxy]-2-[(R)-2-[2-(2-hydroxyacetylamino)acetylamino]-2-(3-methyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-5-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / methanol / 2 h / 20 °C / Inert atmosphere

2: morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; toluene-4-sulfonic acid; In tetrahydrofuran; methanol;
DOI:10.1021/jm1014023