2-(4-Chlorophenyl)-2H-pyrazolo[4,3-c]isoquinolin-3-ol

Base Information

Chemical Name:2-(4-Chlorophenyl)-2H-pyrazolo[4,3-c]isoquinolin-3-ol
CAS No.:137695-83-1
Molecular Formula:C16H10ClN3O
Molecular Weight:295.728
Hs Code.:
ChEMBL ID:CHEMBL445565,CHEMBL3144807
DSSTox Substance ID:DTXSID90568583
Nikkaji Number:J457.725F
Wikidata:Q82454880

Synonyms:137695-83-1;2-(4-Chlorophenyl)-2H-pyrazolo[4,3-c]isoquinolin-3-ol;CHEMBL445565;SCHEMBL8322376;CHEMBL3144807;DTXSID90568583;2-(4-Chlorophenyl)-1,2-dihydro-3H-pyrazolo[4,3-c]isoquinolin-3-one

Suppliers and Price of 2-(4-Chlorophenyl)-2H-pyrazolo[4,3-c]isoquinolin-3-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 2-(4-Chlorophenyl)-2H-pyrazolo[4,3-c]isoquinolin-3-ol

Chemical Property:

XLogP3:4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:295.0512396
Heavy Atom Count:21
Complexity:410

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C=NC3=C2NN(C3=O)C4=CC=C(C=C4)Cl

Technology Process of 2-(4-Chlorophenyl)-2H-pyrazolo[4,3-c]isoquinolin-3-ol

There total 7 articles about 2-(4-Chlorophenyl)-2H-pyrazolo[4,3-c]isoquinolin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 137695-79-5
4-benzyl-2-(p-chlorophenyl)-3-hydroxy-2H-pyrazolo[4,3-c]isoquinolinium hydroxide

: 137695-83-1
2-(4-Chloro-phenyl)-2H-pyrazolo[4,3-c]isoquinolin-3-ol

Guidance literature:: With lithium iodide; In N,N-dimethyl-formamide; for 72h; Heating;
DOI:10.1021/jm00080a024

Reference yield:

: 118-90-1
ortho-methylbenzoic acid

: 137695-83-1
2-(4-Chloro-phenyl)-2H-pyrazolo[4,3-c]isoquinolin-3-ol

Guidance literature:: Multi-step reaction with 6 steps

1: HCl / Heating

2: NBS, benzoyl peroxide / CCl₄ / Heating

3: Et₃N / diethyl ether / Heating

4: sodium ethoxide / benzene / 6 h / Heating

5: 72 percent / ethanol / 24 h / Heating

6: 62 percent / LiI*3H₂O / dimethylformamide / 72 h / Heating

With hydrogenchloride; N-Bromosuccinimide; Perbenzoic acid; sodium ethanolate; triethylamine; lithium iodide; In tetrachloromethane; diethyl ether; ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00080a024

Reference yield:

: 87-24-1
ethyl 2-methylbenzoate

: 137695-83-1
2-(4-Chloro-phenyl)-2H-pyrazolo[4,3-c]isoquinolin-3-ol

Guidance literature:: Multi-step reaction with 5 steps

1: NBS, benzoyl peroxide / CCl₄ / Heating

2: Et₃N / diethyl ether / Heating

3: sodium ethoxide / benzene / 6 h / Heating

4: 72 percent / ethanol / 24 h / Heating

5: 62 percent / LiI*3H₂O / dimethylformamide / 72 h / Heating

With N-Bromosuccinimide; Perbenzoic acid; sodium ethanolate; triethylamine; lithium iodide; In tetrachloromethane; diethyl ether; ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00080a024