(3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-[⁽¹⁴⁾C]-2-(N-methyl-N-(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid

Base Information

• Chemical Name: (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-[⁽¹⁴⁾C]-2-(N-methyl-N-(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid
• CAS No.: 1278406-22-6
• Molecular Formula: C₂₄H₂₉FN₆O₄
• Molecular Weight: 486.519

Synonyms:

Chemical Property of (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-[⁽¹⁴⁾C]-2-(N-methyl-N-(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-[⁽¹⁴⁾C]-2-(N-methyl-N-(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid

There total 9 articles about (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-[⁽¹⁴⁾C]-2-(N-methyl-N-(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-[(14)C]-2-(N-methyl-N-(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate (1278406-20-4) → (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-[(14)C]-2-(N-methyl-N-(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid (1278406-22-6)

Guidance literature:

With hydrogenchloride; water; In acetonitrile; at 40 ℃; for 6h; Inert atmosphere;

DOI:10.1002/jlcr.1810

Reference yield:

methyl 2-[(14)C]-2-chloro-4-(4-fluorophenyl)-6-isopropylpyrimidine-5-carboxylate (1278406-11-3) → (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-[(14)C]-2-(N-methyl-N-(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid (1278406-22-6)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium t-butanolate / N,N-dimethyl-formamide / 2.08 h / 0 - 20 °C / Inert atmosphere

2.1: 1,4-diaza-bicyclo[2.2.2]octane / 6 h / 90 °C / Inert atmosphere

3.1: diisobutylaluminium hydride / toluene / 1.33 h / -78 - 0 °C / Inert atmosphere

3.2: 0.5 h / 0 - 20 °C / Inert atmosphere

4.1: sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; potassium bromide / dichloromethane; water / 1.5 h / 0 - 5 °C / pH 9.15 / Inert atmosphere

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -78 - -70 °C / Inert atmosphere

6.1: hydrogenchloride; water / acetonitrile / 6 h / 40 °C / Inert atmosphere

With 1,4-diaza-bicyclo[2.2.2]octane; hydrogenchloride; sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; water; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium bromide; lithium hexamethyldisilazane; sodium t-butanolate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; 5.1: Julia olefin synthesis;

DOI:10.1002/jlcr.1810

Reference yield:

Methyl 4-methyl-3-oxopentanoate (42558-54-3) → (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-[(14)C]-2-(N-methyl-N-(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid (1278406-22-6)

Guidance literature:

Multi-step reaction with 9 steps

1.1: sulfuric acid; copper(l) chloride / methanol / 114 h / 20 - 65 °C / Inert atmosphere

2.1: nitric acid / 1.17 h / 0 - 20 °C / Inert atmosphere

2.2: 0 °C / pH 6 / Inert atmosphere

3.1: trichlorophosphate / 3 h / 100 °C / Inert atmosphere

4.1: sodium t-butanolate / N,N-dimethyl-formamide / 2.08 h / 0 - 20 °C / Inert atmosphere

5.1: 1,4-diaza-bicyclo[2.2.2]octane / 6 h / 90 °C / Inert atmosphere

6.1: diisobutylaluminium hydride / toluene / 1.33 h / -78 - 0 °C / Inert atmosphere

6.2: 0.5 h / 0 - 20 °C / Inert atmosphere

7.1: sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; potassium bromide / dichloromethane; water / 1.5 h / 0 - 5 °C / pH 9.15 / Inert atmosphere

8.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -78 - -70 °C / Inert atmosphere

9.1: hydrogenchloride; water / acetonitrile / 6 h / 40 °C / Inert atmosphere

With 1,4-diaza-bicyclo[2.2.2]octane; hydrogenchloride; sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sulfuric acid; water; nitric acid; diisobutylaluminium hydride; sodium hydrogencarbonate; copper(l) chloride; potassium bromide; lithium hexamethyldisilazane; sodium t-butanolate; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; 1.1: Biginelli reaction / 8.1: Julia olefin synthesis;

DOI:10.1002/jlcr.1810

upstream raw materials:

methyl 4-(4-fluorophenyl)-6-isopropyl-2-[⁽¹⁴⁾C]-2-(1-methyl-1H-1,2,4-triazol-5-ylamino)pyrimidine-5-carboxylate

methyl 4-(4-fluorophenyl)-6-isopropyl-2-[⁽¹⁴⁾C]-2-(N-methyl-N-(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidine-5-carboxylate

methyl 4-(4-fluorophenyl)-6-isopropyl-2-[⁽¹⁴⁾C]-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

4-(4-fluorophenyl)-6-isopropyl-2-[⁽¹⁴⁾C]-2-(N-methyl-N-(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidine-5-carboxaldehyde

Downstream raw materials:

ammonium (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-[⁽¹⁴⁾C]-2-(N-methyl-N-(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate

C₂₃⁽¹⁴⁾CH₂₇FN₆O₃

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1278406-22-6 (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-[⁽¹⁴⁾C]-2-(N-methyl-N-(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid

Send

Send

Metric Ton KG G Pound L ML

Send

Send