(3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-N-(2-morpholinoethyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamide trifluoroacetate

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Chemical Name:(3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-N-(2-morpholinoethyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamide trifluoroacetate
CAS No.:1410737-90-4
Molecular Formula:C₂HF₃O₂*C₂₉H₃₃Cl₂FN₄O₃
Molecular Weight:689.534
Hs Code.:

(3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-N-(2-morpholinoethyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamide trifluoroacetate

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Chemical Property of (3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-N-(2-morpholinoethyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamide trifluoroacetate

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Technology Process of (3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-N-(2-morpholinoethyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamide trifluoroacetate

There total 4 articles about (3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-N-(2-morpholinoethyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: C₄₃H₄₅Cl₂FN₄O₄

: 76-05-1
trifluoroacetic acid

: 1410737-90-4
(3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-N-(2-morpholinoethyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamide trifluoroacetate

: C₂₉H₃₃Cl₂FN₄O₃*C₂HF₃O₂

Guidance literature:: C₄₃H₄₅Cl₂FN₄O₄; With ammonium cerium (IV) nitrate; In acetonitrile; at 20 ℃; for 0.0833333h; Inert atmosphere;

In water; acetonitrile; Inert atmosphere;

trifluoroacetic acid; In methanol; water; Inert atmosphere;
DOI:10.1021/jm501541j

Reference yield:

: C₄₃H₄₅Cl₂FN₄O₄

: 1410737-90-4
(3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-N-(2-morpholinoethyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamide trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonium cerium (IV) nitrate / acetonitrile / 0.08 h / 20 °C / Inert atmosphere

1.2: Inert atmosphere

1.3: Inert atmosphere

2.1: trifluoroacetic acid / methanol; water / 24 h / Inert atmosphere

With ammonium cerium (IV) nitrate; trifluoroacetic acid; In methanol; water; acetonitrile;
DOI:10.1021/jm501541j