N₁-(4-(1H-pyrazol-1-yl)phenylsulfonyl)-N₄-(2-iodophenyl)-N₁,N₄-dimethylfumaramide

Base Information

• Chemical Name: N₁-(4-(1H-pyrazol-1-yl)phenylsulfonyl)-N₄-(2-iodophenyl)-N₁,N₄-dimethylfumaramide
• CAS No.: 1357178-86-9
• Molecular Formula: C₂₁H₁₉IN₄O₄S
• Molecular Weight: 550.377
• Mol file: 1357178-86-9.mol

Synonyms:

Chemical Property of N₁-(4-(1H-pyrazol-1-yl)phenylsulfonyl)-N₄-(2-iodophenyl)-N₁,N₄-dimethylfumaramide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₁-(4-(1H-pyrazol-1-yl)phenylsulfonyl)-N₄-(2-iodophenyl)-N₁,N₄-dimethylfumaramide

There total 5 articles about N₁-(4-(1H-pyrazol-1-yl)phenylsulfonyl)-N₄-(2-iodophenyl)-N₁,N₄-dimethylfumaramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl (E)-4--4-oxobut-2-enoate (139115-67-6) → N1-(4-(1H-pyrazol-1-yl)phenylsulfonyl)-N4-(2-iodophenyl)-N1,N4-dimethylfumaramide (1357178-86-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 20 °C

1.2: 0 - 20 °C

2.1: ethanol; potassium hydroxide / 20 °C

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / 0 - 20 °C

4.1: triethylamine / dichloromethane / 0 - 20 °C

With oxalyl dichloride; ethanol; sodium hydride; triethylamine; N,N-dimethyl-formamide; potassium hydroxide; In tetrahydrofuran; dichloromethane;

DOI:10.1039/c2cc15670a

Reference yield:

2-iodophenylamine (615-43-0) → N1-(4-(1H-pyrazol-1-yl)phenylsulfonyl)-N4-(2-iodophenyl)-N1,N4-dimethylfumaramide (1357178-86-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 4-methyl-morpholine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / tetrahydrofuran / 0.33 h / 20 °C

2.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 20 °C

2.2: 0 - 20 °C

3.1: ethanol; potassium hydroxide / 20 °C

4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / 0 - 20 °C

5.1: triethylamine / dichloromethane / 0 - 20 °C

With 4-methyl-morpholine; oxalyl dichloride; ethanol; sodium hydride; triethylamine; N,N-dimethyl-formamide; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; potassium hydroxide; In tetrahydrofuran; dichloromethane;

DOI:10.1039/c2cc15670a

Reference yield:

(E)-4-((2-iodophenyl)(methyl)amino)-4-oxobut-2-enoic acid (1011486-79-5) → N1-(4-(1H-pyrazol-1-yl)phenylsulfonyl)-N4-(2-iodophenyl)-N1,N4-dimethylfumaramide (1357178-86-9)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / 0 - 20 °C

2: triethylamine / dichloromethane / 0 - 20 °C

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1039/c2cc15670a

upstream raw materials:

(E)-4-((2-iodophenyl)(methyl)amino)-4-oxobut-2-enoic acid

4-(1H-pyrazol-1-yl)benzene-1-sulfonyl chloride

2-iodophenylamine

ethyl (E)-4--4-oxobut-2-enoate

Refernces