(R)-4-(4-fluorobenzyl)-2-morpholinylmethanol

Base Information

• Chemical Name: (R)-4-(4-fluorobenzyl)-2-morpholinylmethanol
• CAS No.: 156925-21-2
• Molecular Formula: C₁₂H₁₆FNO₂
• Molecular Weight: 225.263
• Mol file: 156925-21-2.mol

Synonyms:

Chemical Property of (R)-4-(4-fluorobenzyl)-2-morpholinylmethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-4-(4-fluorobenzyl)-2-morpholinylmethanol

There total 1 articles about (R)-4-(4-fluorobenzyl)-2-morpholinylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R)-2-[(benzyloxy)methyl]morpholine (135065-70-2) → (R)-4-(4-fluorobenzyl)-2-morpholinylmethanol (156925-21-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 3 g / hydrogen / palladium-on-carbon / ethanol / 50 °C

2: NaI, K₂CO₃ / butan-2-one / 18 h / Heating

With hydrogen; potassium carbonate; sodium iodide; palladium on activated charcoal; In ethanol; butanone;

DOI:10.1248/cpb.42.877

Reference yield:

(R)-4-(4-fluorobenzyl)-2-morpholinylmethanol (156925-21-2) → (S)-(-)-<4-(4-fluorobenzyl)-2-morpholinyl>methylamine (156334-89-3)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 1.) 5 deg C, 2.) RT, 24 h

2: 2.1 g / sodium azide / dimethylformamide / 2 h / 120 °C

3: 70percent sodium bis(2-methoxyethoxy)aluminium hydride / toluene / 1.5 h / -5 - 20 °C

With dmap; sodium azide; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1248/cpb.42.877

Reference yield:

(R)-4-(4-fluorobenzyl)-2-morpholinylmethanol (156925-21-2) → (S)-2-(azidomethyl)-4-(4-fluorobenzyl)morpholine

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 1.) 5 deg C, 2.) RT, 24 h

2: 2.1 g / sodium azide / dimethylformamide / 2 h / 120 °C

With dmap; sodium azide; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.42.877

upstream raw materials:

(2R)-2-[(benzyloxy)methyl]morpholine

Downstream raw materials:

(R)-(-)-<4-(4-fluorobenzyl)-2-morpholinyl>methyl p-toluenesulfonate

(S)-(-)-<4-(4-fluorobenzyl)-2-morpholinyl>methylamine