N-[8-(hydroxymethyl)-1-oxo-1,2,2a,3-tetrahydroazeto[2,1-c][1,4]benzoxazin-2-yl]-2-phenylacetamide

Base Information

• Chemical Name: N-[8-(hydroxymethyl)-1-oxo-1,2,2a,3-tetrahydroazeto[2,1-c][1,4]benzoxazin-2-yl]-2-phenylacetamide
• CAS No.: 68847-89-2
• Molecular Formula: C₁₉H₁₈N₂O₄
• Molecular Weight: 338.363
• Mol file: 68847-89-2.mol

Synonyms:

Chemical Property of N-[8-(hydroxymethyl)-1-oxo-1,2,2a,3-tetrahydroazeto[2,1-c][1,4]benzoxazin-2-yl]-2-phenylacetamide

Chemical Property:

• Vapor Pressure: 1.61E-19mmHg at 25°C

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[8-(hydroxymethyl)-1-oxo-1,2,2a,3-tetrahydroazeto[2,1-c][1,4]benzoxazin-2-yl]-2-phenylacetamide

There total 3 articles about N-[8-(hydroxymethyl)-1-oxo-1,2,2a,3-tetrahydroazeto[2,1-c][1,4]benzoxazin-2-yl]-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-{8-[(tert-butyl-dimethyl-silanyloxy)-methyl]-1-oxo-(2ar)-1,2,2a,3-tetrahydro-azeto[1,2-d]benzo[b][1,4]oxazin-2t-yl}-2-phenyl-acetamide (68847-90-5) → N-(8-hydroxymethyl-1-oxo-(2ar)-1,2,2a,3-tetrahydro-azeto[1,2-d]benzo[b][1,4]oxazin-2t-yl)-2-phenyl-acetamide (68847-89-2)

Guidance literature:

With trifluoroacetic acid; In tetrahydrofuran; water; for 0.25h; Ambient temperature;

Reference yield:

3r-azido-1-[2-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-4c-methanesulfonyloxymethyl-azetidin-2-one → N-(8-hydroxymethyl-1-oxo-(2ar)-1,2,2a,3-tetrahydro-azeto[1,2-d]benzo[b][1,4]oxazin-2t-yl)-2-phenyl-acetamide (68847-89-2)

Guidance literature:

Multi-step reaction with 3 steps

1: KF, 18-crown-6 / acetonitrile / Ambient temperature

2: (i) H₂S, Et₃N, CH₂Cl₂, (ii) /BRN= 742254/

3: CF₃CO₂H / tetrahydrofuran; H₂O / 0.25 h / Ambient temperature

With potassium fluoride; 18-crown-6 ether; trifluoroacetic acid; In tetrahydrofuran; water; acetonitrile;

Reference yield:

2t-azido-8-(tert-butyl-dimethyl-silanyloxymethyl)-(2ar)-2a,3-dihydro-2H-azeto[1,2-d]benzo[b][1,4]oxazin-1-one → N-(8-hydroxymethyl-1-oxo-(2ar)-1,2,2a,3-tetrahydro-azeto[1,2-d]benzo[b][1,4]oxazin-2t-yl)-2-phenyl-acetamide (68847-89-2)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) H₂S, Et₃N, CH₂Cl₂, (ii) /BRN= 742254/

2: CF₃CO₂H / tetrahydrofuran; H₂O / 0.25 h / Ambient temperature

With trifluoroacetic acid; In tetrahydrofuran; water;

upstream raw materials:

N-{8-[(tert-butyl-dimethyl-silanyloxy)-methyl]-1-oxo-(2ar)-1,2,2a,3-tetrahydro-azeto[1,2-d]benzo[b][1,4]oxazin-2t-yl}-2-phenyl-acetamide