18anti,19anti-bis-((Ξ)-acetoxy-phenyl-methyl)-4,5α-epoxy-3,6-dimethoxy-17-methyl-6β,14-ethano-morphin-7-ene

Base Information

• Chemical Name: 18anti,19anti-bis-((Ξ)-acetoxy-phenyl-methyl)-4,5α-epoxy-3,6-dimethoxy-17-methyl-6β,14-ethano-morphin-7-ene
• CAS No.: 54249-39-7
• Molecular Formula: C₃₉H₄₁NO₇
• Molecular Weight: 635.757
• Mol file: 54249-39-7.mol

Synonyms:

Chemical Property of 18anti,19anti-bis-((Ξ)-acetoxy-phenyl-methyl)-4,5α-epoxy-3,6-dimethoxy-17-methyl-6β,14-ethano-morphin-7-ene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 18anti,19anti-bis-((Ξ)-acetoxy-phenyl-methyl)-4,5α-epoxy-3,6-dimethoxy-17-methyl-6β,14-ethano-morphin-7-ene

There total 3 articles about 18anti,19anti-bis-((Ξ)-acetoxy-phenyl-methyl)-4,5α-epoxy-3,6-dimethoxy-17-methyl-6β,14-ethano-morphin-7-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

thebaine (115-37-7) → 18anti,19anti-bis-((Ξ)-acetoxy-phenyl-methyl)-4,5α-epoxy-3,6-dimethoxy-17-methyl-6β,14-ethano-morphin-7-ene (54249-39-7)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene / 8 h / Heating

2: LiAlH₄ / tetrahydrofuran / 3.5 h / Heating

3: Py / 63 h / Ambient temperature

With pyridine; lithium aluminium tetrahydride; In tetrahydrofuran; toluene;

DOI:10.1016/S0040-4020(01)97290-4

Reference yield:

C,C'-diphenyl-C,C'-(4,5α-epoxy-3,6-dimethoxy-17-methyl-6α,14α-etheno-morphinane-7α,8α-diyl)-bis-methanone (54169-83-4) → 18anti,19anti-bis-((Ξ)-acetoxy-phenyl-methyl)-4,5α-epoxy-3,6-dimethoxy-17-methyl-6β,14-ethano-morphin-7-ene (54249-39-7)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄ / tetrahydrofuran / 3.5 h / Heating

2: Py / 63 h / Ambient temperature

With pyridine; lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1016/S0040-4020(01)97290-4

Reference yield:

acetic anhydride (108-24-7) + C,C'-diphenyl-C,C'-(4,5α-epoxy-3,6-dimethoxy-17-methyl-6α,14α-etheno-morphinane-7α,8α-diyl)-bis-methanol (54249-38-6) → 18anti,19anti-bis-((Ξ)-acetoxy-phenyl-methyl)-4,5α-epoxy-3,6-dimethoxy-17-methyl-6β,14-ethano-morphin-7-ene (54249-39-7)

Guidance literature:

With pyridine; for 63h; Ambient temperature;

DOI:10.1016/S0040-4020(01)97290-4

upstream raw materials:

acetic anhydride

C,C'-diphenyl-C,C'-(4,5α-epoxy-3,6-dimethoxy-17-methyl-6α,14α-etheno-morphinane-7α,8α-diyl)-bis-methanol

thebaine

C,C'-diphenyl-C,C'-(4,5α-epoxy-3,6-dimethoxy-17-methyl-6α,14α-etheno-morphinane-7α,8α-diyl)-bis-methanone