1-(phenylsulfonyl)benzocyclobutene

Base Information

• Chemical Name: 1-(phenylsulfonyl)benzocyclobutene
• CAS No.: 71721-16-9
• Molecular Formula: C₁₄H₁₂O₂S
• Molecular Weight: 244.314
• Mol file: 71721-16-9.mol

Synonyms:

Chemical Property of 1-(phenylsulfonyl)benzocyclobutene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(phenylsulfonyl)benzocyclobutene

There total 8 articles about 1-(phenylsulfonyl)benzocyclobutene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-chloro-2-<2-(phenylsulfonyl)ethyl>benzene (71721-13-6) → 1-(phenylsulfonyl)benzocyclobutene (71721-16-9)

Guidance literature:

With potassium amide; ferric nitrate;

Reference yield:

2-chlorophenylacetic acid ethyl ester (40061-54-9) → 1-(phenylsulfonyl)benzocyclobutene (71721-16-9)

Guidance literature:

Multi-step reaction with 5 steps

1: LiAlH₄ / diethyl ether

2: SOCl₂, pyridine

3: NaOEt / ethanol / Heating

4: aq. H₂O₂

5: K, liq. NH₃ / liquid ammonia

With pyridine; lithium aluminium tetrahydride; thionyl chloride; ammonia; dihydrogen peroxide; sodium ethanolate; In diethyl ether; ethanol; ammonia;

DOI:10.1021/jo01058a019

Reference yield:

2-(2-chlorophenyl)-1-ethanol (19819-95-5) → 1-(phenylsulfonyl)benzocyclobutene (71721-16-9)

Guidance literature:

Multi-step reaction with 4 steps

1: SOCl₂, pyridine

2: NaOEt / ethanol / Heating

3: aq. H₂O₂

4: K, liq. NH₃ / liquid ammonia

With pyridine; thionyl chloride; ammonia; dihydrogen peroxide; sodium ethanolate; In ethanol; ammonia;

DOI:10.1021/jo01058a019

upstream raw materials:

1-chloro-2-<2-(phenylsulfonyl)ethyl>benzene

2-chlorophenylacetic acid ethyl ester

2-(2-chlorophenyl)-1-ethanol

2-chlorophenylethyl chloride

Downstream raw materials:

7-Benzenesulfonyl-7-pent-4-enyl-bicyclo[4.2.0]octa-1,3,5-triene

7-Allyl-7-benzenesulfonyl-bicyclo[4.2.0]octa-1,3,5-triene

7-Benzenesulfonyl-7-but-3-enyl-bicyclo[4.2.0]octa-1,3,5-triene

Refernces