2-[4-(4-Fluorophenyl)piperazin-1-yl]ethanamine

Base Information

• Chemical Name: 2-[4-(4-Fluorophenyl)piperazin-1-yl]ethanamine
• CAS No.: 27144-84-9
• Molecular Formula: C₁₂H₁₈FN₃
• Molecular Weight: 223.293
• ChEMBL ID: CHEMBL4530921
• DSSTox Substance ID: DTXSID30602657
• Wikidata: Q82499799
• Mol file: 27144-84-9.mol

Synonyms:27144-84-9;2-[4-(4-fluorophenyl)piperazin-1-yl]ethanamine;2-[4-(4-FLUOROPHENYL)PIPERAZIN-1-YL]ETHAN-1-AMINE;2-(4-(4-fluorophenyl)piperazin-1-yl)ethan-1-amine;F2187-2190;SCHEMBL1307372;CHEMBL4530921;DTXSID30602657;AKOS000151417;AB51088;CS-0450551;EN300-37340;VU0490386-1;G34167;{2-[4-(4-fluorophenyl)piperazin-1-yl]ethyl}amine;J-016679;Z285207352

Chemical Property of 2-[4-(4-Fluorophenyl)piperazin-1-yl]ethanamine

Chemical Property:

• Boiling Point: 138-142 °C(Press: 0.05 Torr)
• PKA: 10.11±0.10(Predicted)
• Density: 1.126±0.06 g/cm3(Predicted)
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 223.14847575
• Heavy Atom Count: 16
• Complexity: 196

Purity/Quality:

98%Min ^*data from raw suppliers

2-[4-(4-fluorophenyl)piperazin-1-yl]ethan-1-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1CCN)C2=CC=C(C=C2)F

Technology Process of 2-[4-(4-Fluorophenyl)piperazin-1-yl]ethanamine

There total 3 articles about 2-[4-(4-Fluorophenyl)piperazin-1-yl]ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-Fluorophenyl)piperazine (2252-63-3) → 2-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethylamine (27144-84-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 70 °C

2: hydrazine hydrate / ethanol / 70 °C

With potassium carbonate; hydrazine hydrate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1002/cmdc.201300474

Reference yield:

1-(4-Fluorophenyl)piperazine (2252-63-3) → 2-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethylamine (27144-84-9)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / dimethylformamide / 2 h / 80 °C

2: hidrazine / ethanol / 5 h / 70 °C

With potassium carbonate; hydrazine; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2004.06.011

Reference yield:

→ 2-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethylamine (27144-84-9)

Guidance literature:

Chloracetonitril, 1-(4-Fluorphenyl)-piperazin, K2CO3, NH3, H2/Raney-Ni;

upstream raw materials:

1-(4-Fluorophenyl)piperazine

Downstream raw materials:

N-{2-[4-(4-fluorophenyl)piperazin-1-yl]ethyl}-2-naphthalenecarboxamide

N⁵-(2-(4-(4-fluorophenyl)piperazin-1-yl)ethyl)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine

C₂₅H₃₁FN₄O*ClH

N-{2-[4-(4-fluorophenyl)piperazin-1-yl]ethyl}-2-quinoxaline carboxamide