Technology Process of 4-Nitro-benzoic acid (2S,3S,4S,6R)-6-acetoxy-2-methyl-3-(2,2,2-trifluoro-acetylamino)-tetrahydro-pyran-4-yl ester
There total 9 articles about 4-Nitro-benzoic acid (2S,3S,4S,6R)-6-acetoxy-2-methyl-3-(2,2,2-trifluoro-acetylamino)-tetrahydro-pyran-4-yl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 1.) oxyde de dibutyletain; 2.) iodure de tetrabutylammonium / 1.) benzene, reflux, 16 h; 2.) reflux, 6 h
2: 60 percent / pyridine / 48 h, r. t. then 48 h, r. t.
3: 97 percent / azoture de sodium / dimethylformamide / 18 h / 100 °C
4: triethylamine, H2 / 10 percent Pd-C / ethanol / 1.5 h / 750.06 Torr
5: triethylamine / CH2Cl2 / 0.25 h / Ambient temperature
6: 88 percent / H2 / Pd-C / ethanol / 24 h / 750.06 Torr
7: 85 percent / pyridine / 3 h / 0 °C
8: 92 mg / acide acetique / 3 h / Heating
9: pyridine / Ambient temperature
With
azoture de sodium; oxyde de dibutyletain; hydrogen; tetra-(n-butyl)ammonium iodide; acetic acid; triethylamine;
palladium on activated charcoal;
In
pyridine; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0008-6215(87)80044-7
- Guidance literature:
-
Multi-step reaction with 5 steps
1: triethylamine / CH2Cl2 / 0.25 h / Ambient temperature
2: 88 percent / H2 / Pd-C / ethanol / 24 h / 750.06 Torr
3: 85 percent / pyridine / 3 h / 0 °C
4: 92 mg / acide acetique / 3 h / Heating
5: pyridine / Ambient temperature
With
hydrogen; acetic acid; triethylamine;
palladium on activated charcoal;
In
pyridine; ethanol; dichloromethane;
DOI:10.1016/0008-6215(87)80044-7
- Guidance literature:
-
Multi-step reaction with 6 steps
1: triethylamine, H2 / 10 percent Pd-C / ethanol / 1.5 h / 750.06 Torr
2: triethylamine / CH2Cl2 / 0.25 h / Ambient temperature
3: 88 percent / H2 / Pd-C / ethanol / 24 h / 750.06 Torr
4: 85 percent / pyridine / 3 h / 0 °C
5: 92 mg / acide acetique / 3 h / Heating
6: pyridine / Ambient temperature
With
hydrogen; acetic acid; triethylamine;
palladium on activated charcoal;
In
pyridine; ethanol; dichloromethane;
DOI:10.1016/0008-6215(87)80044-7
