3-butyl-4-fluoroisoquinoline hydrochloride

Base Information

• Chemical Name: 3-butyl-4-fluoroisoquinoline hydrochloride
• CAS No.: 1453382-78-9
• Molecular Formula: C₁₃H₁₄FN*ClH
• Molecular Weight: 239.72
• Mol file: 1453382-78-9.mol

Synonyms:

Chemical Property of 3-butyl-4-fluoroisoquinoline hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-butyl-4-fluoroisoquinoline hydrochloride

There total 1 articles about 3-butyl-4-fluoroisoquinoline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-butyl-4-fluoroisoquinoline (1404078-10-9) → 3-butyl-4-fluoroisoquinoline hydrochloride (1453382-78-9)

Guidance literature:

With hydrogenchloride; In diethyl ether; at 20 ℃; for 0.005h;

DOI:10.1039/c3cc45341c

Reference yield:

3-butyl-4-fluoroisoquinoline hydrochloride (1453382-78-9) → C20H21BrFNO

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; bis(1,5-cyclooctadiene)diiridium(I) dichloride; (+)-(R)-[2,3,2',3'-tetrahydro-5,5'-bi(1,4-benzodioxin)-6,6'-diyl]bis(diphenylphosphane); 1,3-dichloro-5,5-dimethylhydantoin / 1,4-dioxane; isopropyl alcohol / 20 h / 30 °C / 30003 Torr

2: triethylamine / dichloromethane / 0.5 h

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; 1,3-dichloro-5,5-dimethylhydantoin; hydrogen; triethylamine; (+)-(R)-[2,3,2',3'-tetrahydro-5,5'-bi(1,4-benzodioxin)-6,6'-diyl]bis(diphenylphosphane); In 1,4-dioxane; dichloromethane; isopropyl alcohol;

DOI:10.1039/c3cc45341c

Reference yield:

3-butyl-4-fluoroisoquinoline hydrochloride (1453382-78-9) → (3R,4R)-3-butyl-4-fluoro-1,2,3,4-tetrahydroisoquinoline (1453382-51-8)

Guidance literature:

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; 1,3-dichloro-5,5-dimethylhydantoin; hydrogen; (+)-(R)-[2,3,2',3'-tetrahydro-5,5'-bi(1,4-benzodioxin)-6,6'-diyl]bis(diphenylphosphane); In 1,4-dioxane; isopropyl alcohol; at 30 ℃; for 20h; under 30003 Torr; Reagent/catalyst; Solvent; enantioselective reaction;

DOI:10.1039/c3cc45341c

upstream raw materials:

3-butyl-4-fluoroisoquinoline

Downstream raw materials:

(3R,4R)-3-butyl-4-fluoro-1,2,3,4-tetrahydroisoquinoline