(2-{[4-chloro-3-(6-chloro-4-methyl-pyridin-3-yl)-benzoyl]-methyl-amino}-phenoxy)-acetic acid

Base Information

Chemical Name:(2-{[4-chloro-3-(6-chloro-4-methyl-pyridin-3-yl)-benzoyl]-methyl-amino}-phenoxy)-acetic acid
CAS No.:1070889-68-7
Molecular Formula:C₂₂H₁₈Cl₂N₂O₄
Molecular Weight:445.302
Hs Code.:

Synonyms:

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Chemical Property of (2-{[4-chloro-3-(6-chloro-4-methyl-pyridin-3-yl)-benzoyl]-methyl-amino}-phenoxy)-acetic acid

Chemical Property:

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Technology Process of (2-{[4-chloro-3-(6-chloro-4-methyl-pyridin-3-yl)-benzoyl]-methyl-amino}-phenoxy)-acetic acid

There total 7 articles about (2-{[4-chloro-3-(6-chloro-4-methyl-pyridin-3-yl)-benzoyl]-methyl-amino}-phenoxy)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42860-10-6
3-bromo-4-chlorobenzoic acid

: 1070889-68-7
(2-{[4-chloro-3-(6-chloro-4-methyl-pyridin-3-yl)-benzoyl]-methyl-amino}-phenoxy)-acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h

2.1: sodium hydrogencarbonate / water; acetonitrile / 1.5 h

2.2: 16 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 80 °C

4.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 14 h / 95 °C

5.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 12 h / 95 °C

6.1: lithium hydroxide; water / tetrahydrofuran / 20 °C

With lithium hydroxide; oxalyl dichloride; water; potassium acetate; sodium hydrogencarbonate; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 21900-34-5
3-bromo-4-chlorobenzoyl chloride

: 1070889-68-7
(2-{[4-chloro-3-(6-chloro-4-methyl-pyridin-3-yl)-benzoyl]-methyl-amino}-phenoxy)-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / water; acetonitrile / 1.5 h

1.2: 16 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 80 °C

3.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 14 h / 95 °C

4.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 12 h / 95 °C

5.1: lithium hydroxide; water / tetrahydrofuran / 20 °C

With lithium hydroxide; water; potassium acetate; sodium hydrogencarbonate; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1070892-07-7
3-bromo-4-chloro-N-(2-methoxy-phenyl)-N-methyl-benzamide

: 1070889-68-7
(2-{[4-chloro-3-(6-chloro-4-methyl-pyridin-3-yl)-benzoyl]-methyl-amino}-phenoxy)-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: boron tribromide / dichloromethane / 12.33 h / -70 - 20 °C

1.2: pH ~ 5

2.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 80 °C

3.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 14 h / 95 °C

4.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 12 h / 95 °C

5.1: lithium hydroxide; water / tetrahydrofuran / 20 °C

With lithium hydroxide; water; potassium acetate; boron tribromide; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;