(R)-2-(Benzhydrylidene-amino)-4-chloro-pent-4-enoic acid (1R,2S,4S)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Base Information

Chemical Name:(R)-2-(Benzhydrylidene-amino)-4-chloro-pent-4-enoic acid (1R,2S,4S)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester
CAS No.:130157-15-2
Molecular Formula:C₄₀H₅₃ClN₂O₄S
Molecular Weight:693.391
Hs Code.:

(R)-2-(Benzhydrylidene-amino)-4-chloro-pent-4-enoic acid (1R,2S,4S)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

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Chemical Property of (R)-2-(Benzhydrylidene-amino)-4-chloro-pent-4-enoic acid (1R,2S,4S)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

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Technology Process of (R)-2-(Benzhydrylidene-amino)-4-chloro-pent-4-enoic acid (1R,2S,4S)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

There total 14 articles about (R)-2-(Benzhydrylidene-amino)-4-chloro-pent-4-enoic acid (1R,2S,4S)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 99295-72-4
(+)-(1R,2S,4S)-N,N-dicyclohexyl-7,7-dimethyl-2-hydroxybicyclo[2.2.1]heptane-1-methanesulfonamide

: 130157-15-2
(S)-2-(Benzhydrylidene-amino)-4-chloro-pent-4-enoic acid (1R,2S,4S)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / N,N-diethylaniline / diethyl ether / Heating

2: 91 percent / NaN₃ / acetone; H₂O / Heating

3: 95 percent / hydrogen / Pd/BaSO₄ / methanol

4: 92 percent / HCl (gas) / diethyl ether / 2 h

5: 94 percent / CH₂Cl₂ / 24 h / Ambient temperature

6: 1.) lithium diisopropylamide / 1.) -78 deg C, THF, 2.) -50 deg C, 4 h

With hydrogenchloride; sodium azide; hydrogen; N,N-diethylaniline; lithium diisopropyl amide; Pd-BaSO₄; In methanol; diethyl ether; dichloromethane; water; acetone;
DOI:10.1016/S0040-4039(00)94713-0

Reference yield:

: 99295-72-4
(+)-(1R,2S,4S)-N,N-dicyclohexyl-7,7-dimethyl-2-hydroxybicyclo[2.2.1]heptane-1-methanesulfonamide

: 130157-15-2
(R)-2-(Benzhydrylidene-amino)-4-chloro-pent-4-enoic acid (1R,2S,4S)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / N,N-diethylaniline / diethyl ether / Heating

2: 91 percent / NaN₃ / acetone; H₂O / Heating

3: 95 percent / hydrogen / Pd/BaSO₄ / methanol

4: 92 percent / HCl (gas) / diethyl ether / 2 h

5: 94 percent / CH₂Cl₂ / 24 h / Ambient temperature

6: 1.) lithium diisopropylamide / 1.) -78 deg C, THF, 2.) -50 deg C, 4 h

With hydrogenchloride; sodium azide; hydrogen; N,N-diethylaniline; lithium diisopropyl amide; Pd-BaSO₄; In methanol; diethyl ether; dichloromethane; water; acetone;
DOI:10.1016/S0040-4039(00)94713-0

Reference yield:

: 130195-80-1
Chloro-acetic acid (1R,2S,4S)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

: 130157-15-2
(S)-2-(Benzhydrylidene-amino)-4-chloro-pent-4-enoic acid (1R,2S,4S)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / NaN₃ / acetone; H₂O / Heating

2: 95 percent / hydrogen / Pd/BaSO₄ / methanol

3: 92 percent / HCl (gas) / diethyl ether / 2 h

4: 94 percent / CH₂Cl₂ / 24 h / Ambient temperature

5: 1.) lithium diisopropylamide / 1.) -78 deg C, THF, 2.) -50 deg C, 4 h

With hydrogenchloride; sodium azide; hydrogen; lithium diisopropyl amide; Pd-BaSO₄; In methanol; diethyl ether; dichloromethane; water; acetone;
DOI:10.1016/S0040-4039(00)94713-0